About: Potential mechanism and drug candidates for sepsis-induced acute lung injury

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About: Potential mechanism and drug candidates for sepsis-induced acute lung injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential mechanism and drug candidates for sepsis-induced acute lung injury
Creator	Wang, Zheng Guo, Zhengqiang Xu, Chenyuan Zhang, Xufeng Zhao, Chuncheng
topic	covid:1dfb38c44ff4bd4534b37c8f42f3e18c282e66e7#this
Source	PMC
abstract	The present study aimed to explore the mechanisms underlying sepsis-induced acute lung injury (ALI) and identify more effective therapeutic strategies to treat it. The gene expression data set GSE10474 was downloaded and assessed to identify differentially expressed genes (DEGs). Principal component analysis, functional enrichment analysis and differential co-expression analysis of DEGs were performed. Furthermore, potential target drugs for key DEGs were assessed. A total of 209 DEGs, including 107 upregulated and 102 downregulated genes were screened. A number of DEGs, including zinc finger and BTB domain containing 17 (ZBTB17), heat shock protein 90 kDa β, member 1 (HSP90B1) and major histocompatibility complex, class II, DR α were identified. Furthermore, gene ontology terms including antigen processing and presentation, glycerophospholipid metabolism, transcriptional misregulation in cancer, thyroid hormone synthesis and pathways associated with diseases, such as asthma were identified. In addition, a differential co-expression network containing ubiquitin-conjugating enzyme E2 D4, putative and tubulin, γ complex associated protein 3 was constructed. Furthermore, a number of gene-drug interactions, including between HSP90B1 and adenosine-5′-diphosphate and radicicol, were identified. Therefore, DEGs, including ZBTB17 and HSP90B1, may be important in the pathogenesis of sepsis-induced ALI. Furthermore, drugs including adenosine-5′-diphosphate may be novel drug candidates to treat patients with ALI.
has issue date	2018-03-28(xsd:dateTime)
bibo:doi	10.3892/etm.2018.6001
bibo:pmid	29805488
has license	cc-by-nc-nd
sha1sum (hex)	1dfb38c44ff4bd4534b37c8f42f3e18c282e66e7
schema:url	https://doi.org/10.3892/etm.2018.6001
resource representing a document's title	Potential mechanism and drug candidates for sepsis-induced acute lung injury
has PubMed Central identifier	PMC5952104
has PubMed identifier	29805488
schema:publication	Exp Ther Med
resource representing a document's body	covid:1dfb38c44ff4bd4534b37c8f42f3e18c282e66e7#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/1dfb38c44ff4bd4534b37c8f42f3e18c282e66e7
is schema:about of	named entity 'CONSTRUCTED' named entity 'HORMONE SYNTHESIS' named entity 'DIPHOSPHATE' named entity 'DRUG INTERACTIONS' named entity 'TUBULIN' named entity 'HSP90B1' named entity 'UNDERLYING' named entity 'PRINCIPAL COMPONENT ANALYSIS' named entity 'PROTEIN 3' named entity 'GENE ONTOLOGY' named entity 'THYROID HORMONE' named entity 'IMPORTANT' named entity 'UPREGULATED' named entity 'HEAT SHOCK PROTEIN 90' named entity 'TO IDENTIFY' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX' named entity 'DATA SET' named entity 'INDUCED' named entity 'UBIQUITIN-CONJUGATING ENZYME E2 D4' named entity 'MEMBER' named entity 'GENES' named entity 'PATHOGENESIS' named entity 'glycerophospholipid metabolism' named entity 'diphosphate' named entity 'gene ontology' named entity 'number' named entity 'strategies' named entity 'acute lung injury' named entity 'presentation' named entity 'asthma' named entity 'acute lung injury' named entity 'SEPSIS' named entity 'GENE EXPRESSION DATA' named entity 'DRUGS' named entity 'DISEASES' named entity 'ANTIGEN PROCESSING AND PRESENTATION' named entity 'POTENTIAL' named entity 'IDENTIFY' named entity 'FUNCTIONAL ENRICHMENT ANALYSIS' named entity 'TOTAL' named entity 'ACUTE LUNG INJURY' named entity 'TRANSCRIPTIONAL MISREGULATION IN CANCER' named entity 'ADENOSINE' named entity 'MECHANISM' named entity 'ACUTE LUNG INJURY' named entity 'INDUCED' named entity 'DRUG' named entity 'NETWORK' named entity 'ASSOCIATED' named entity 'ZINC FINGER AND BTB DOMAIN CONTAINING 17' named entity 'PATHWAYS' named entity 'CO-EXPRESSION ANALYSIS' named entity 'MECHANISMS' named entity 'ONTOLOGY TERMS' named entity 'TARGET' named entity 'PATIENTS' named entity 'RADICICOL' named entity 'THERAPEUTIC' named entity 'COMPLEX' named entity 'EXPRESSED' named entity 'DEGS' named entity 'STRATEGIES' named entity '102' named entity 'DIFFERENTIAL' named entity 'EFFECTIVE' named entity 'CO-EXPRESSION' named entity 'STUDY' named entity 'CLASS II' named entity 'ASSOCIATED WITH' named entity 'PRESENT' named entity 'ZBTB17' named entity 'GENE' named entity 'ASTHMA' named entity 'SEPSIS' named entity 'INCLUDING'

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