About: Unexpected receptor functional mimicry elucidates activation of coronavirus fusion

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
Creator	Corti, Davide Lanzavecchia, Antonio Zambon, Maria Cameroni, Elisabetta Snijder, Joost Veesler, David Xiong, Xiaoli Walls, Alexandra Gopal, Robin Park, Young-Jun Dai, Mian Quispe, Joel Correspondence, David Rey, A Tortorici, M
Source	Elsevier; Medline; PMC
abstract	Recent outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome along with the threat of a future coronavirus-mediated pandemic underscore the importance of finding ways to combat these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and is the major target of neutralizing antibodies. To understand the humoral immune response elicited upon natural infections with coronaviruses, we structurally characterized the SARS-CoV and MERS-CoV S glycoproteins in complex with neutralizing antibodies isolated from human survivors. Although the two antibodies studied blocked attachment to the host cell receptor, only the anti-SARS-CoV S antibody triggered fusogenic conformational changes via receptor functional mimicry. These results provide a structural framework for understanding coronavirus neutralization by human antibodies and shed light on activation of coronavirus membrane fusion, which takes place through a receptor-driven ratcheting mechanism.
has issue date	2019-02-01(xsd:dateTime)
bibo:doi	10.1016/j.cell.2018.12.028
bibo:pmid	30712865
has license	hybrid-oa
sha1sum (hex)	1fd8f1880c1e04c879d89eab5311b06cfd7f2ddc
schema:url	https://doi.org/10.1016/j.cell.2018.12.028
resource representing a document's title	Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
has PubMed Central identifier	PMC6751136
has PubMed identifier	30712865
schema:publication	Cell
resource representing a document's body	covid:1fd8f1880c1e04c879d89eab5311b06cfd7f2ddc#body_text
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