About: Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
Creator	Ludewig, Burkhard Takaoka, Akinori Aderem, Alan Baazim, Hatoon Bergthaler, Andreas Bhattacharya, Anannya Kosack, Lindsay Superti-Furga, Giulio Cupovic, Jovana Arnold, Isabelle Colinge, Jacques Deigendesch, Nikolaus Flatz, Lukas Hildebrandt, Andrea Khamina, Kseniya Merkler, Doron Panse, Isabel Schliehe, Christopher Vilagos, Bojan Hegazy, Ahmed Kandasamy, Richard Lang, Philipp Xu, Haifeng Kü, Anja Lö, Max
Source	Elsevier; Medline; PMC
abstract	Tissue damage caused by viral hepatitis is a major cause of morbidity and mortality worldwide. Using a mouse model of viral hepatitis, we identified virus-induced early transcriptional changes in the redox pathways in the liver, including downregulation of superoxide dismutase 1 (Sod1). Sod1(−/−) mice exhibited increased inflammation and aggravated liver damage upon viral infection, which was independent of T and NK cells and could be ameliorated by antioxidant treatment. Type I interferon (IFN-I) led to a downregulation of Sod1 and caused oxidative liver damage in Sod1(−/−) and wild-type mice. Genetic and pharmacological ablation of the IFN-I signaling pathway protected against virus-induced liver damage. These results delineate IFN-I mediated oxidative stress as a key mediator of virus-induced liver damage and describe a mechanism of innate-immunity-driven pathology, linking IFN-I signaling with antioxidant host defense and infection-associated tissue damage. VIDEO ABSTRACT:
has issue date	2015-11-17(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2015.10.013
bibo:pmid	26588782
has license	cc-by
sha1sum (hex)	2034ca5a9941b6e3d8b0ba9280a5b2fae192778d
schema:url	https://doi.org/10.1016/j.immuni.2015.10.013
resource representing a document's title	Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
has PubMed Central identifier	PMC4658338
has PubMed identifier	26588782
schema:publication	Immunity
resource representing a document's body	covid:2034ca5a9941b6e3d8b0ba9280a5b2fae192778d#body_text
is schema:about of	named entity 'ARTICLE' named entity 'CORRESPONDENCE' named entity 'VIRAL HEPATITIS' named entity 'STAT1' named entity 'SOD1' named entity 'LEADS' named entity 'REDOX' named entity 'HEPATOCYTES' named entity 'MICE' named entity 'INCLUDING' named entity 'AMELIORATES' named entity 'VIRAL INFECTION' named entity 'ABLATION' named entity 'OXIDATIVE DAMAGE' named entity 'EXHIBIT' named entity 'DRIVEN' named entity 'TYPE I INTERFERON' named entity 'EARLY' named entity 'DRIVES' named entity 'IFN' named entity 'ANTIOXIDANTS' named entity 'AGGRAVATED' named entity 'SIGNALING' named entity 'SUPEROXIDE DISMUTASE 1' named entity 'ACCESSION NUMBER' named entity 'DOWNREGULATION' named entity '80%' named entity 'LIVER DAMAGE' named entity 'liver damage' named entity 'Sod1' named entity 'antioxidants' named entity 'Viral infection' named entity 'Damage' named entity 'viral hepatitis' named entity 'mice' named entity 'downregulation' named entity 'STAT1' named entity 'downregulation' named entity 'Viral infection' named entity 'Hepatocytes' named entity 'Type I Interferon' named entity 'Oxidative Damage' named entity 'Hepatocytes' named entity 'antioxidants' named entity 'molecular mechanism' named entity 'Cre' named entity 'S4D' named entity 'Statistical significance' named entity '8 days' named entity 'FACS' named entity 'innate immunity' named entity 'tissue damage' named entity 'liver' named entity 'SOD' named entity 'SOD1' named entity 'Sod1' named entity 'Sod1'

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