About: C-reactive protein, haptoglobin, serum amyloid A and pig major acute phase protein response in pigs simultaneously infected with H1N1 swine influenza virus and Pasteurella multocida

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About: C-reactive protein, haptoglobin, serum amyloid A and pig major acute phase protein response in pigs simultaneously infected with H1N1 swine influenza virus and Pasteurella multocida Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	C-reactive protein, haptoglobin, serum amyloid A and pig major acute phase protein response in pigs simultaneously infected with H1N1 swine influenza virus and Pasteurella multocida
Creator	Pejsak, Zygmunt Kwit, Krzysztof Markowska-Daniel, Iwona Pomorska-Mól, Małgorzata Stępniewska, Katarzyna
Source	PMC
abstract	BACKGROUND: Swine influenza (SI) is an acute respiratory disease caused by swine influenza virus (SIV). Swine influenza is generally characterized by acute onset of fever and respiratory symptoms. The most frequent complications of influenza are secondary bacterial pneumonia. The objective of this work was to study the acute phase proteins (APP) responses after coinfection of piglets with H1N1 swine influenza virus (SwH1N1) and Pasteurella multocida (Pm) in order to identify whether the individual APP response correlate with disease severity and whether APP could be used as markers of the health status of coinfected pigs. RESULTS: In all coinfected pigs clinical sings, including fever, coughing and dyspnea, were seen. Viral shedding was observed from 2 to 7 dpi. The mean level of antibodies against Pm dermonecrotoxin in infected piglets increase significantly from 7 dpi. Anti-SwH1N1 antibodies in the serum were detected from 7 dpi. The concentration of C-reactive protein (CRP) increased significantly at 1 dpi as compared to control pigs, and remained significantly higher to 3 dpi. Level of serum amyloid A (SAA) was significantly higher from 2 to 3 dpi. Haptoglobin (Hp) was significantly elevated from 3 dpi to the end of study, while pig major acute phase protein (Pig-MAP) from 3 to 7 dpi. The concentrations of CRP, Hp and SAA significantly increased before specific antibodies were detected. Positive correlations were found between serum concentration of Hp and SAA and lung scores, and between clinical score and concentrations of Pig-MAP and SAA. CONCLUSIONS: The results of current study confirmed that monitoring of APP may revealed ongoing infection, and in this way may be useful in selecting clinically healthy pigs (i.e. before integration into an uninfected herd). Present results corroborated our previous findings that SAA could be a potentially useful indicator in experimental infection studies (e.g. vaccine efficiency investigations) or as a marker for disease severity, because of correlation observed between its concentration in serum and disease severity (lung scores, clinical scores).
has issue date	2013-01-18(xsd:dateTime)
bibo:doi	10.1186/1746-6148-9-14
bibo:pmid	23332090
has license	cc-by
sha1sum (hex)	21083480591a0f89c6c6a1ee575c79ef9eeaeb75
schema:url	https://doi.org/10.1186/1746-6148-9-14
resource representing a document's title	C-reactive protein, haptoglobin, serum amyloid A and pig major acute phase protein response in pigs simultaneously infected with H1N1 swine influenza virus and Pasteurella multocida
has PubMed Central identifier	PMC3554491
has PubMed identifier	23332090
schema:publication	BMC Vet Res
resource representing a document's body	covid:21083480591a0f89c6c6a1ee575c79ef9eeaeb75#body_text
is schema:about of	named entity 'fever' named entity 'H1N1' named entity 'virus' named entity 'C-reactive protein' named entity 'COINFECTION' named entity 'PIGS' named entity 'STUDY' named entity 'INDIVIDUAL' named entity 'ORDER' named entity 'COULD BE' named entity 'HEALTH STATUS' named entity 'FEVER' named entity 'SWINE INFLUENZA' named entity 'ACUTE PHASE PROTEINS' named entity 'COMPLICATIONS' named entity 'SWINE INFLUENZA VIRUS' named entity 'MARKERS' named entity 'DISEASE SEVERITY' named entity 'RESPONSE' named entity 'H1N1 SWINE INFLUENZA VIRUS' named entity 'PROTEIN ' named entity 'PIG' named entity 'INFLUENZA' named entity '28PM' covid:arg/21083480591a0f89c6c6a1ee575c79ef9eeaeb75 named entity 'ACUTE ONSET' named entity 'ACUTE PHASE PROTEIN' named entity 'ONSET OF' named entity 'ACUTE RESPIRATORY DISEASE' named entity 'OBJECTIVE' named entity 'SIMULTANEOUSLY' named entity 'HAPTOGLOBIN' named entity 'RESPONSE' named entity 'INFECTED' named entity 'SERUM AMYLOID A' named entity 'RESPONSES' named entity 'APP' named entity 'USED' named entity 'FREQUENT' named entity 'GENERALLY' named entity 'RESPIRATORY SYMPTOMS' named entity 'PIGS' named entity 'MAJOR' named entity 'C-REACTIVE PROTEIN' named entity 'CAUSED BY' named entity 'TO IDENTIFY' named entity 'PASTEURELLA MULTOCIDA' named entity 'CHARACTERIZED' named entity 'SECONDARY BACTERIAL PNEUMONIA' named entity 'H1N1 SWINE INFLUENZA VIRUS' named entity 'WORK' named entity 'BACKGROUND' named entity 'PASTEURELLA MULTOCIDA ' named entity 'study' named entity 'correlation' named entity 'turbinates' named entity 'bacteria' named entity 'coinfection' named entity 'co-infection' named entity 'H1N2' named entity 'SIV' named entity 'APP' named entity 'acute phase proteins' named entity 'simultaneously' named entity 'APP' named entity 'swine influenza' named entity 'Swine influenza' named entity 'virus' named entity 'haptoglobin' named entity 'amyloid' named entity 'gene' named entity 'gene' named entity 'AIV' named entity 'respiratory rate' named entity 'Haptoglobin' named entity 'pathogens' named entity 'SIV'

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