About: Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis

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About: Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis
Creator	Jylhävä, Juulia Lipcsey, Miklós Castegren, Markus Hurme, Mikko Larsson, Alexander Nyberg, Axel Sperber, Jesper
Source	PMC
abstract	BACKGROUND: Plasma levels of cell-free DNA (cf-DNA) are known to be elevated in sepsis and high levels are associated with a poor prognosis. Mechanical ventilation affects systemic inflammation in which lung-protective ventilation attenuates the inflammatory response. The aim was to study the effect of a lung protective ventilator regime on arterial and organ-specific venous blood as well as on trans-organ differences in cf-DNA levels in a porcine post-operative sepsis model. METHOD: One group of anaesthetised, domestic-breed, 9–12 weeks old, pigs were ventilated with protective ventilation (V(T) 6 mL x kg(− 1), PEEP 10 cmH(2)O) n = 20. Another group, ventilated with a medium high tidal volume and lower PEEP, served as a control group (V(T) 10 mL x kg(− 1), PEEP 5 cm H(2)O) n = 10. Blood samples were taken from four sources: artery, hepatic vein, portal vein and, jugular bulb. A continuous endotoxin infusion at 0.25 μg x kg(− 1) x h(− 1) for 5 h was started following 2 h of laparotomy, which simulated a surgical procedure. Inflammatory cytokines and cf-DNA in plasma were analysed and trans-organ differences calculated. RESULTS: The protective ventilation group had lower levels of cf-DNA in arterial (p = 0.02) and hepatic venous blood (p = 0.03) compared with the controls. Transhepatic differences in cf-DNA were lower in the protective group, compared with the controls (p = 0.03). No differences between the groups were noted as regards the transcerebral, transsplanchnic or the transpulmonary cf-DNA differences. CONCLUSIONS: Protective ventilation suppresses arterial levels of cf-DNA. The liver seems to be a net contributor to the systemic cf-DNA levels, but this effect is attenuated by protective ventilation.
has issue date	2020-07-31(xsd:dateTime)
bibo:doi	10.1186/s12890-020-01239-y
has license	cc-by
sha1sum (hex)	21150530d631a2b6080c41be627c1ed55f65f257
schema:url	https://doi.org/10.1186/s12890-020-01239-y
resource representing a document's title	Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis
has PubMed Central identifier	PMC7393331
schema:publication	BMC Pulm Med
resource representing a document's body	covid:21150530d631a2b6080c41be627c1ed55f65f257#body_text
is schema:about of	named entity 'levels' named entity 'Plasma' named entity 'systemic' named entity 'sepsis' named entity 'CELL-FREE DNA' named entity 'VENTILATION' covid:arg/21150530d631a2b6080c41be627c1ed55f65f257 named entity 'attenuates' named entity 'DNA' named entity 'aim' named entity 'high' named entity 'post-operative' named entity 'prognosis' named entity 'venous blood' named entity 'Plasma levels' named entity 'sepsis' named entity 'high levels' named entity 'hepatic vein' named entity 'lactate' named entity 'portal circulation' named entity 'bolus' named entity 'external jugular vein' named entity 'afferent' named entity 'immunosuppressive' named entity 'interquartile range' named entity 'intensive care' named entity '1, 2' named entity 'sepsis' named entity 'septic shock' named entity 'endotoxin' named entity 'porcine' named entity 'portal vein' named entity 'Stockholm' named entity 'IL-6' named entity 'intravenous' named entity 'Uppsala' named entity 'Carlsbad, CA' named entity 'IL-6' named entity 'MPAP' named entity 'plasma' named entity 'organ' named entity 'sodium' named entity 'Invitrogen' named entity 'IL-10' named entity 'general anaesthesia' named entity 'porcine' named entity 'analysis of variance' named entity 'bolus' named entity 'plasma levels' named entity 'IL-10' named entity 'cardiac arrest' named entity 'IL-6' named entity 'stroke' named entity 'Plasma' named entity 'organ' named entity 'airway' named entity 'plasma' named entity 'IL-10' named entity 'laparotomy' named entity 'IL-6' named entity 'TNF-α' named entity 'septic shock' named entity 'hepatic' named entity 'ARRI' named entity 'infusion' named entity 'IL-6' named entity 'cytokines' named entity 'assay' named entity 'ad libitum' named entity 'one-way analysis of variance' named entity 'GE Healthcare' named entity 'interleukin 10' named entity 'airway' named entity 'lymphoid tissue' named entity 'hepatic vein' named entity 'coagulation' named entity 'heart atrium'

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