About: HLA-associated protection of lymphocytes during influenza virus infection

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About: HLA-associated protection of lymphocytes during influenza virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	HLA-associated protection of lymphocytes during influenza virus infection
Creator	Nichols, Joan Domurat, Frank El-Daher, Nayef Huda, Ruksana Mock, David Ochoa, Eliana Roberts, Norbert Scheibel, Steven
source	PMC
abstract	BACKGROUND: Heterozygosity at HLA class I loci is generally considered beneficial for host defense. We report here an element of HLA class I homozygosity that may or may not help preserve its existence in populations but which could indicate a new avenue for antiviral research. METHODS: Lymphocytes from serologically HLA-homozygous or -heterozygous donors were examined for synthesis of influenza virus proteins and RNA after exposure to virus as peripheral blood mononuclear cells. The virus-exposed lymphocytes were also examined for internalization of the virus after exposure, and for susceptibility to virus-specific cytotoxic T lymphocytes in comparison with virus-exposed monocytes/macrophages and unseparated peripheral blood mononuclear cells. Results were compared using two-tailed Fisher’s exact test. RESULTS: Serologically-defined HLA-A2-homozygous lymphocytes, in contrast to heterozygous lymphocytes, did not synthesize detectable influenza virus RNA or protein after exposure to the virus. HLA-A2-homozygous lymphocytes, including both homozygous and heterozygous donors by genetic sequence subtyping, did internalize infectious virus but were not susceptible to lysis by autologous virus-specific cytotoxic T lymphocytes (“fratricide”). Similar intrinsic resistance to influenza virus infection was observed with HLA-A1- and HLA-A11-homozygous lymphocytes and with HLA-B-homozygous lymphocytes. CONCLUSIONS: A significant proportion of individuals within a population that is characterized by common expression of HLA class I alleles may possess lymphocytes that are not susceptible to influenza virus infection and thus to mutual virus-specific lysis. Further study may identify new approaches to limit influenza virus infection.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1186/s12985-020-01406-x
bibo:pmid	32831108
has license	cc-by
sha1sum (hex)	2169f8f89f889b149a96a04173f334c4ae9ae685
schema:url	https://doi.org/10.1186/s12985-020-01406-x
resource representing a document's title	HLA-associated protection of lymphocytes during influenza virus infection
has PubMed Central identifier	PMC7444183
has PubMed identifier	32831108
schema:publication	Virol J
resource representing a document's body	covid:2169f8f89f889b149a96a04173f334c4ae9ae685#body_text
is schema:about of	named entity 'influenza' named entity 'virus' named entity 'METHODS' named entity 'COMPARISON' covid:arg/2169f8f89f889b149a96a04173f334c4ae9ae685 named entity 'antiviral' named entity 'serologically' named entity 'internalization' named entity 'virus' named entity 'peripheral blood mononuclear cells' named entity 'peripheral blood mononuclear cells' named entity 'HLA' named entity 'virus' named entity 'virus' named entity 'Heterozygosity' named entity 'infection' named entity 'lymphocytes' named entity 'homozygous' named entity 'lytic' named entity 'lymphocytes' named entity 'influenza virus' named entity 'Invitrogen' named entity 'lymphocytes' named entity 'epithelial cells' named entity 'virus' named entity 'homozygous' named entity 'autologous' named entity 'morbidity' named entity 'virus' named entity 'virus' named entity 'statistically significant' named entity 'cytotoxic T lymphocyte' named entity 'radiolabeled' named entity 'lymphocytes' named entity 'primers' named entity 'IAV' named entity 'donor number' named entity 'monocytes' named entity 'FITC' named entity 'lysates' named entity 'serologically' named entity 'virus' named entity 'influenza virus' named entity 'macrophages' named entity 'cell lysates' named entity 'homozygous' named entity 'heterozygous' named entity 'homozygous' named entity 'HLA-A2' named entity 'CTL' named entity 'University of Rochester' named entity 'monocytes' named entity 'homozygosity' named entity 'proteases' named entity 'lymphocytes' named entity 'PBMC' named entity 'HLA' named entity 'HLA-B' named entity 'CTL' named entity 'exposure to the virus' named entity 'fixed and stained' named entity 'H1N1' named entity 'methylene blue' named entity 'lymphocytes' named entity 'homozygous' named entity 'apoptosis' named entity 'lung' named entity 'immunoprecipitated' named entity 'infection' named entity 'lymphocytes' named entity 'heterozygous' named entity 'lung' named entity 'influenza virus' named entity 'HLA-A2'

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