About: Up-regulation of p21 and TNF-α is mediated in lycorine-induced death of HL-60 cells

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About: Up-regulation of p21 and TNF-α is mediated in lycorine-induced death of HL-60 cells Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Up-regulation of p21 and TNF-α is mediated in lycorine-induced death of HL-60 cells
Creator	Liu, Jing He, Yan Hu, Wei-Xin Shi, Bi-Wei Hu, Ji-Liang
source	Medline; PMC
abstract	BACKGROUND: Leukemia is one of the most life-threatening cancers today, and acute promyelogenous leukemia (APL) is a common type of leukemia. Many natural compounds have already been found to exhibit significant anti-tumor effects. Lycorine, a natural alkaloid extracted from Amaryllidaceae, exhibited anti-leukemia effects in vitro and in vivo. The survival rate of HL-60 cells exposed to lycorine was decreased, cell growth was slowed down, and cell regeneration potential was inhibited. HL-60 cells exhibited typical apoptotic characteristic. Lycorine can suppress leukemia growth and reduce cell survival and inducing apoptosis of tumor cells. The purpose of this work is to elucidate the mechanism by which lycorine induces APL cells. RESULTS: When HL-60 cells were treated with different concentration of lycorine, the expression of p21 and TNF-α was up-regulated in a concentration-dependent manner as shown by real-time quantitative reverse transcriptase-polymerase chain reaction and Western blotting. Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IκB phosphorylation and blocked NF-κB nuclear import. Cytochrome c was released from mitochondria as observed with confocal laser microscopy. CONCLUSIONS: The TNF-α signal transduction pathway and p21-mediated cell-cycle inhibition were involved in the apoptosis of HL-60 cells induced by lycorine. These results contribute to the development of new lycorine-based anti-leukemia drugs.
has issue date	2010-08-04(xsd:dateTime)
bibo:doi	10.1186/1475-2867-10-25
bibo:pmid	20682078
has license	cc-by
sha1sum (hex)	217e7ecb495478a12b89de6ab9d03e629f478752
schema:url	https://doi.org/10.1186/1475-2867-10-25
resource representing a document's title	Up-regulation of p21 and TNF-α is mediated in lycorine-induced death of HL-60 cells
has PubMed Central identifier	PMC2924328
has PubMed identifier	20682078
schema:publication	Cancer Cell Int
resource representing a document's body	covid:217e7ecb495478a12b89de6ab9d03e629f478752#body_text
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