About: Assessment of Inactivation Procedures for SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Assessment of Inactivation Procedures for SARS-CoV-2
Creator	Garcia-Rivera, Jose Karlsson, Erik Auerswald, Heidi Martin, Nicholas Dul, Sokha Dussart, In, Saraden Yann, Sokhoun
Source	BioRxiv
abstract	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease 2019 (COVID-19), presents a challenge to laboratorians and healthcare workers around the world. Handling of biological samples from individuals infected with the SARS-CoV-2 virus requires strict biosafety and biosecurity measures. Within the laboratory, non-propagative work with samples containing the virus requires, at minimum, Biosafety Level-2 (BSL-2) techniques and facilities. Therefore, handling of SARS-CoV-2 samples remains a major concern in areas and conditions where biosafety and biosecurity for specimen handling is difficult to maintain, such as in rural laboratories or austere field testing sites. Inactivation through physical or chemical means can reduce the risk of handling live virus and increase testing ability worldwide. Herein we assess several chemical and physical inactivation techniques employed against SARS-CoV-2 isolates from Cambodian COVID-19 patients. This data demonstrates that all chemical (AVL, inactivating sample buffer and formaldehyde) and heat treatment (56°C and 98°C) methods tested completely inactivated viral loads of up to 5 log10.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.1101/2020.05.28.120444
has license	biorxiv
sha1sum (hex)	22d35e96761e9a75b8d58431574be3a67cc18ada
schema:url	https://doi.org/10.1101/2020.05.28.120444
resource representing a document's title	Assessment of Inactivation Procedures for SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:22d35e96761e9a75b8d58431574be3a67cc18ada#body_text
is schema:about of	covid:arg/22d35e96761e9a75b8d58431574be3a67cc18ada named entity 'Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)' named entity 'disinfectant' named entity 'WHO' named entity 'coronaviruses' named entity 'SARS-CoV-2' named entity 'MERS' named entity 'statistical significance' named entity 'Berlin' named entity 'AVL' named entity 'heat treatment' named entity 'Polyethylene glycol' named entity 'virus' named entity 'AVL' named entity 'lysis' named entity 'algorithm' named entity 'viral RNA' named entity 'Dunnett's test' named entity 'nucleic acid' named entity 'biosafety' named entity 'Vero' named entity 'MERS' named entity 'RNA' named entity 'infection' named entity 'log10' named entity 'virus' named entity 'log10' named entity 'log10' named entity 'incubation' named entity 'Formaldehyde' named entity 'virus' named entity 'sampling' named entity 'SARS-CoV-2' named entity 'viral lysis' named entity 'virus' named entity 'St. Louis' named entity 'PBS' named entity 'lysis' named entity 'Formaldehyde' named entity 'SARS' named entity 'virus' named entity 'SARS-CoV-2' named entity 'virus' named entity 'AVL' named entity 'RT-PCR' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'PBS' named entity 'viral lysis' named entity 'titer' named entity 'viruses' named entity 'RT-PCR' named entity 'Qiagen' named entity 'viruses' named entity 'detergents' named entity 'negative control' named entity 'RT-PCR' named entity 'SARS-CoV-2' named entity 'Vero E6' named entity 'heat treatment' named entity 'RdRp' named entity 'SARS-CoV-2' named entity 'virus' named entity 'formaldehyde' named entity 'RNA' named entity 'SARS-CoV-2' named entity 'viral load' named entity 'SARS-CoV-2' named entity 'Germany' named entity 'real-time RT-PCR' named entity 'TCID50' named entity 'chaotropic agents' named entity 'virus' named entity 'centrifugation' named entity 'SARS-CoV-2' named entity 'MERS'

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