About: A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic
Creator	Fonseca, João Oliveira-Ramos, Filipa Romeu, José Romão, Vasco Cristino, José Barreira, Sofia Cruz-Machado, Ana Khmelinskii, Nikita Martins, Patrícia Mendonça-Galaio, Luís Proença, Helena Sacadura-Leite, Ema Silva-Dinis, Joana
source	MedRxiv
abstract	Objectives: To describe our experience with a coronavirus disease 2019 (COVID-19) outbreak within a large rheumatology department, early in the pandemic. Methods: Symptomatic and asymptomatic healthcare workers (HCWs) had a naso-oropharyngeal swab for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and were followed clinically. Reverse transcription polymerase-chain reaction (RT-PCR) was repeated to document cure, and serological response was assessed. Patients with risk contacts within the department in the 14 days preceding the outbreak were screened for COVID-19 symptoms. Results: 14/34 HCWs (41%; 40{+/-}14 years, 71% female) tested positive for SARS-CoV-2, and 11/34 (32%) developed symptoms but were RT-PCR-negative. Half of RT-PCR-positive HCWs did not report fever, cough, or dyspnoea before testing, which were absent in 3/14 cases (21%). Mild disease prevailed (79%), but 3 HCWs had moderate disease requiring further assessment, which excluded severe complications. Nevertheless, symptom duration (28{+/-}18 days), viral shedding (31{+/-}10 days post-symptom onset, range 15-51) and work absence (29{+/-}28 days) were prolonged. 13/14 (93%) of RT-PCR-positive and none of the RT-PCR-negative HCWs had a positive humoral response, with higher IgG-index in individuals over 50 years (14.5{+/-}7.7 vs 5.0{+/-}4.4, p=0.012). Of 617 rheumatic patients, 8 (1.3%) developed COVID-19 symptoms (1/8 hospitalisation, 8/8 complete recovery), following a consultation/procedure with an asymptomatic (7/8) or mildly-symptomatic (1/8) HCW. Conclusions: A COVID-19 outbreak can occur among HCWs and rheumatic patients, swiftly spreading over the presymptomatic stage. Mild disease without typical symptoms should be recognised, and may evolve with delayed viral shedding, prolonged recovery, and adequate immune response in most individuals.
has issue date	2020-06-08(xsd:dateTime)
bibo:doi	10.1101/2020.06.05.20107011
has license	medrxiv
sha1sum (hex)	23e0cd1c4683d7fd18143312aa72c90b7af42410
schema:url	https://doi.org/10.1101/2020.06.05.20107011
resource representing a document's title	A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic
resource representing a document's body	covid:23e0cd1c4683d7fd18143312aa72c90b7af42410#body_text
is schema:about of	named entity 'outbreak' named entity 'pandemic' named entity 'PANDEMIC' named entity 'coronavirus disease 2019' named entity 'rheumatology' named entity 'HCW' named entity 'SARS-CoV-2' named entity 'preprint' named entity 'RT-PCR' named entity 'fever' named entity 'symptom' named entity 'peer review' named entity 'pneumonia' named entity 'serology' named entity 'immune response' named entity 'healthcare facilities' named entity 'Italy' named entity 'antibody response' named entity 'IgM' named entity 'giant cell arteritis' named entity 'azithromycin' named entity 'preprint' named entity 'respiratory symptoms' named entity 'medRxiv' named entity 'medRxiv' named entity 'RT-PCR' named entity 'medRxiv' named entity 'myalgia' named entity 'preprint' named entity 'peer review' named entity 'medRxiv' named entity 'preprint' named entity 'medRxiv' named entity 'dysgeusia' named entity 'cough' named entity 'methotrexate' named entity 'COVID-19' named entity 'World Health Organization' named entity 'asymptomatic' named entity 'SARS-CoV-2' named entity 'viral load' named entity 'gastrointestinal symptoms' named entity 'COVID-19' named entity 'symptom' named entity 'peer review' named entity 'Wuhan' named entity 'SARS-CoV-2' named entity 'long-term' named entity 'RT-PCR' named entity 'RT-PCR' named entity 'serological tests' named entity 'chronic obstructive pulmonary disease' named entity 'outpatient clinic' named entity 'medRxiv' named entity 'symptom' named entity 'preprint' named entity 'Nasopharyngeal swabs' named entity 'asymptomatic' named entity 'RMDs' named entity 'cough' named entity 'severe pneumonia' named entity 'peer review' named entity 'rheumatology' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'receptor' named entity 'RT-PCR' named entity 'asymptomatic carriers' named entity 'headache' named entity 'preprint' named entity 'high volume' named entity 'anosmia' named entity 'preprint' named entity 'index case'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software