About: In vivo and in vitro models of demyelinating disease of coronaviruses in primary explants of the rat CNS XI. Tropism and differentiation regulate the infectious process of coronaviruses in primary explants of the rat CNS

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About: In vivo and in vitro models of demyelinating disease of coronaviruses in primary explants of the rat CNS XI. Tropism and differentiation regulate the infectious process of coronaviruses in primary explants of the rat CNS Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vivo and in vitro models of demyelinating disease of coronaviruses in primary explants of the rat CNS XI. Tropism and differentiation regulate the infectious process of coronaviruses in primary explants of the rat CNS
Creator	Dales, S Beushausen, S
Source	Elsevier; Medline; PMC
abstract	Abstract The coronaviruses, ubiquitous in mammals, including man, manifest serotype-related predeliction for different tissues. This presentation deals with specificity of the murine viscerotropic MHV3 and neurotropic JHMV for explanted cells from the CNS of newborn, inbred, Wistar-Furth rats. An unambiguous tropism of MHV3 for astrocytes and JHMV for oligodendrocytes is demonstrated. With the latter cell-virus interaction, relatively small differences in spatial density of oligodendrocytes influence profoundly the duration of persistence and virus yield. The in vitro temporal program of oligodendrocyte differentiation, monitored by induction of a myelin-related enzyme, 2′:3′-cyclic nucleotide-3′-phosphohydrolase, corresponds to that occurring in vivo (F. A. McMorris, J. Neurochem. 41, 506–515, 1983). It is complete within 15–21 days and is coincident with the onset of insusceptibility to disease caused by JHMV. Experimental elevation of intracellular cyclic-AMP levels, presumed to reflect oligodendrocyte differentiation, likewise suppresses JHMV replication without affecting that of MHV3 in astrocytes. On the basis of these data it is concluded that in vitro interaction of JHMV with oligodendrocytes reflects accurately the in vivo host control over the tropism and expression of this virus, thereby effecting the progressive, demyelinative disease, process.
has issue date	1985-02-28(xsd:dateTime)
bibo:doi	10.1016/0042-6822(85)90185-0
bibo:pmid	2983498
has license	els-covid
sha1sum (hex)	249a7d9c3b06ef2d4f1ac0b8ed74a741cd586b03
schema:url	https://doi.org/10.1016/0042-6822%2885%2990185-0
resource representing a document's title	In vivo and in vitro models of demyelinating disease of coronaviruses in primary explants of the rat CNS XI. Tropism and differentiation regulate the infectious process of coronaviruses in primary explants of the rat CNS
has PubMed Central identifier	PMC7131688
has PubMed identifier	2983498
schema:publication	Virology
resource representing a document's body	covid:249a7d9c3b06ef2d4f1ac0b8ed74a741cd586b03#body_text
is schema:about of	named entity 'CNS' named entity 'Tropism' named entity 'Regulate' named entity 'DIFFERENTIATION' named entity 'REGULATE' named entity 'PRIMARY' named entity 'MODELS' named entity 'INFECTIOUS PROCESS' named entity 'TROPISM' named entity 'DEMYELINATING DISEASE' named entity 'RAT' named entity 'IN VITRO' named entity 'CNS' named entity 'CORONAVIRUSES' named entity 'Explants' named entity 'serotypes' named entity 'neurotropic' named entity 'multiplicity of infection' named entity 'avidity' named entity 'virus' named entity 'morphology' named entity 'necrosis' named entity 'Infection' named entity 'triturated' named entity 'myelin' named entity 'infection' named entity 'neonates' named entity 'oligodendrocyte' named entity 'GFAP' named entity 'lo5' named entity 'PBS' named entity 'Virus replication' named entity 'intraperitoneal' named entity 'demyelinating disease' named entity 'centrifuged' named entity 'complement' named entity 'cell lines' named entity 'tropism' named entity 'Ind.' named entity 'CNS' named entity 'neurons' named entity 'oligodendrocytes' named entity 'cell-cell contacts' named entity 'infection' named entity 'Protein' named entity 'oligodendrocyte' named entity 'cell types' named entity 'glycolipid' named entity 'syringe' named entity 'postpartum' named entity 'neurons' named entity 'IgG' named entity 'Elmsford' named entity 'neonatal' named entity 'tropisms' named entity 'age-related' named entity 'rat' named entity 'MBP' named entity 'Hank's balanced salt solution' named entity 'antibodies' named entity 'oligodendrocytes' named entity 'rat' named entity 'N. Y.' named entity 'antibodies' named entity 'papaverine' named entity 'supernatant' named entity 'humidified' named entity 'cell lines' named entity 'guinea pig' named entity 'BSA' named entity 'postpartum' named entity 'antibodies' named entity 'density dependence' named entity 'CNS' named entity 'antisera' named entity 'Elkhart' named entity 'Ficoll' named entity 'virus' named entity 'plastic' named entity 'antibody'

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