About: COVID-19: Drug Targets and Potential Treatments

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19: Drug Targets and Potential Treatments
Creator	Alonso, Covadonga Barrado-Gil, Lucía Martinez, Ana Campillo, Nuria Ángel Cuesta-Geijo, Miguel Gil, Carmen Ginex, Tiziana Maestro, Ineś Nozal, Vanesa Ramírez, David Urquiza, Jesuś
source	Medline; PMC
abstract	[Image: see text] Currently, humans are immersed in a pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health worldwide. To date, no drug or vaccine has been approved to treat the severe disease caused by this coronavirus, COVID-19. In this paper, we will focus on the main virus-based and host-based targets that can guide efforts in medicinal chemistry to discover new drugs for this devastating disease. In principle, all CoV enzymes and proteins involved in viral replication and the control of host cellular machineries are potentially druggable targets in the search for therapeutic options for SARS-CoV-2. This Perspective provides an overview of the main targets from a structural point of view, together with reported therapeutic compounds with activity against SARS-CoV-2 and/or other CoVs. Also, the role of innate immune response to coronavirus infection and the related therapeutic options will be presented.
has issue date	2020-06-08(xsd:dateTime)
bibo:doi	10.1021/acs.jmedchem.0c00606
bibo:pmid	32511912
has license	no-cc
sha1sum (hex)	258d280490ea476c44692ba10c5f7ea8385689fd
schema:url	https://doi.org/10.1021/acs.jmedchem.0c00606
resource representing a document's title	COVID-19: Drug Targets and Potential Treatments
has PubMed Central identifier	PMC7323060
has PubMed identifier	32511912
schema:publication	J Med Chem
resource representing a document's body	covid:258d280490ea476c44692ba10c5f7ea8385689fd#body_text
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