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About:
Multiplex PCR tests sentinel the appearance of pandemic influenza viruses including H1N1 swine influenza
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Multiplex PCR tests sentinel the appearance of pandemic influenza viruses including H1N1 swine influenza
Creator
Mahony, James
Petrich, Astrid
Chong, Sylvia
Luinstra, Kathy
Smieja, Marek
Tang, Patrick
Petric, Martin
Ojkic, Davor
Gubbay, Jonathan
Hatchette, Todd
Drews, Steven
Low, Donald
source
Elsevier; Medline; PMC
abstract
BACKGROUND: Since the turn of the century seven new respiratory viruses have infected man and two of these have resulted in worldwide epidemics. Both SARS Coronavirus which quickly spread to 29 countries in February 2003 and H1N1 swine influenza that recently spread from Mexico to 30 countries in three weeks represent major pandemic threats for mankind. Diagnostic assays are required to detect novel influenza strains with pandemic potential. OBJECTIVE: In this report we evaluate the ability of a multiplex PCR test (xTAG(™)RVP) to detect new, “non-seasonal” influenza viruses including the H1N1 swine influenza A/swine/California/04/2009. STUDY DESIGN: Laboratory based study using retrospective and prospective specimens. RESULTS: This multiplex PCR test detected the present of non-seasonal (non-H1, non-H3) influenza in 20 of 20 patients infected with H1N1 swine flu virus. In addition to detecting the current swine flu the xTAG(™) RVP test detected the H5N1 A/Vietnam/1203/2004 high pathogenicity avian influenza virus that circulated in South East Asia in 2003 as well as 17 out of 17 influenza A viruses representing 11 HA subtypes isolated from birds, swine and horses not yet seen in the human population. CONCLUSION: Based on these results we believe that this molecular test can perform an important role as a sentinel test to detect novel non-seasonal influenza A viruses in patients presenting with influenza-like illness (ILI) and therefore act as an early warning system for the detection of future pandemic influenza threats.
has issue date
2009-07-01
(
xsd:dateTime
)
bibo:doi
10.1016/j.jcv.2009.05.031
bibo:pmid
19515609
has license
green-oa
sha1sum (hex)
275030b6878222f9d1c216f7a748879ea943ee06
schema:url
https://doi.org/10.1016/j.jcv.2009.05.031
resource representing a document's title
Multiplex PCR tests sentinel the appearance of pandemic influenza viruses including H1N1 swine influenza
has PubMed Central identifier
PMC5153328
has PubMed identifier
19515609
schema:publication
Journal of Clinical Virology
resource representing a document's body
covid:275030b6878222f9d1c216f7a748879ea943ee06#body_text
is
schema:about
of
named entity 'H1N1'
named entity 'APPEARANCE'
named entity 'INFLUENZA VIRUSES'
named entity 'TESTS'
named entity 'INCLUDING'
named entity 'PANDEMIC'
named entity 'SENTINEL'
named entity 'MULTIPLEX PCR'
named entity 'SWINE INFLUENZA'
named entity 'swine influenza'
named entity 'pandemic influenza viruses'
named entity 'H1N1'
named entity 'influenza'
named entity 'seasonal influenza'
named entity 'viruses'
named entity 'influenza'
named entity 'swine influenza'
named entity 'gene'
named entity 'Mexico'
named entity 'Coronavirus'
named entity 'swine flu'
named entity 'swine influenza'
named entity 'neuraminidase'
named entity 'influenza'
named entity 'seasonal influenza'
named entity 'influenza'
named entity 'pathogenicity'
named entity 'avian influenza viruses'
named entity 'ILI'
named entity 'Mexico'
named entity 'pandemic influenza'
named entity 'metapneumovirus'
named entity 'parainfluenza'
named entity 'California'
named entity 'influenza viruses'
named entity 'seasonal influenza'
named entity 'H1N1'
named entity 'multiplex PCR'
named entity 'virus'
named entity 'ILI'
named entity 'Ontario'
named entity 'enterovirus'
named entity 'zoonotic swine flu'
named entity 'multiplex PCR'
named entity 'California'
named entity 'epidemiologic'
named entity 'coronavirus'
named entity 'H1N1 swine flu'
named entity 'influenza'
named entity 'seasonal influenza'
named entity 'viruses'
named entity 'PCR testing'
named entity 'influenza'
named entity 'H5N1'
named entity 'hemagglutinin'
named entity 'viruses'
named entity 'influenza'
named entity 'seasonal influenza'
named entity 'gene'
named entity 'H1N1'
named entity 'H1N1'
named entity 'H5N1'
named entity 'gene'
named entity 'swine influenza'
named entity 'avian influenza virus'
named entity 'swine influenza'
named entity 'virus'
named entity 'H1N1 swine flu'
named entity 'swine influenza'
named entity 'H1N1'
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