About: Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker
Creator	Balzarini, Jan Piotrowska, Dorota G1owacka, Iwona
Source	Elsevier; Medline; PMC
abstract	Abstract Azidation (TMSN3, SnCl4) of a 9:1 mixture of trans- and cis-5-acetoxy-2-methylisoxazolidin-3-yl-3-phosphonates at the anomeric carbon atom led to the formation of the equimolar mixture of cis- and trans-5-azido-2-methylisoxazolidin-3-yl-3-phosphonates, which were efficiently separated. The 1,3-dipolar cycloaddition of pure trans- and cis-5-azidoisoxazolidin-3-yl-3-phosphonates with selected alkynes gave the respective nucleoside mimetics containing a 1,2,3-triazole linker. The (1,2,3-triazolyl)isoxazolidine phosphonates obtained herein were evaluated in vitro for activity against a variety of DNA and RNA viruses. None of the compounds were endowed with antiviral activity at subtoxic concentrations. Compounds 15f–j and 16f–j were cytostatic in the higher micromolar range.
has issue date	2012-01-31(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2011.11.021
bibo:pmid	22137458
has license	els-covid
sha1sum (hex)	27cab2cf9fe1f84644c25648574436feca5eba98
schema:url	https://doi.org/10.1016/j.ejmech.2011.11.021
resource representing a document's title	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker
has PubMed Central identifier	PMC7125624
has PubMed identifier	22137458
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:27cab2cf9fe1f84644c25648574436feca5eba98#body_text
is schema:about of	named entity 'LINKER' named entity 'ANTIVIRAL' covid:arg/27cab2cf9fe1f84644c25648574436feca5eba98 named entity 'TRIAZOLE' named entity 'NOVEL' named entity 'EVALUATION' named entity 'HAC4' named entity 'PURE' named entity 'CIS' named entity '28S' named entity 'RANGE' named entity 'IN VITRO' named entity 'OBTAINED' named entity 'PHOSPHONATES' named entity '1.8' named entity '8.4' named entity 'CONTAINING' named entity 'LED' named entity 'CYTOSTATIC' named entity 'MHZ' named entity 'ACETOXY' named entity 'DNA' named entity 'ISOXAZOLIDINE' named entity 'SEPARATED' named entity '2.1' named entity '6.9' named entity 'GAVE' named entity 'AZIDATION' named entity 'TRANS' named entity 'SYNTHESIS' named entity 'CYTOSTATIC' named entity 'NMR' named entity 'DESIGN' named entity 'ISOXAZOLIDINE' named entity 'FORMATION' named entity 'ANTIVIRAL ACTIVITY' named entity 'ALKYNES' named entity '0.94' named entity '0.92' named entity 'NUCLEOTIDE' named entity 'MIXTURE' named entity 'TRIAZOLE' named entity '17.7' named entity 'HIGHER' named entity 'HC3' named entity 'AZIDO' named entity 'RNA VIRUSES' named entity 'CARBON ATOM' named entity 'EVALUATED' named entity 'HC5' named entity 'MICROMOLAR' named entity 'NUCLEOSIDE' named entity 'ACTIVITY' named entity 'MIMETICS' named entity 'VARIETY' named entity '13.5' named entity 'SELECTED' named entity 'CYCLOADDITION' named entity 'LINKER' named entity 'CONCENTRATIONS' named entity 'leukaemia' named entity 'broadspectrum' named entity 'virus' named entity 'antiviral activity' named entity 'cytotoxicity' named entity 'conformational analysis' named entity '250 mM' named entity 'cis' named entity 'NMR spectra' named entity '75.5' named entity 'phosphonate' named entity 'virus' named entity 'VZV' named entity 'aqueous' named entity 'silica gel' named entity 'Starting Materials' named entity 'fibroblast' named entity 'azides' named entity 'cis'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software