About: Elucidating the Role of Host Long Non-Coding RNA during Viral Infection: Challenges and Paths Forward

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elucidating the Role of Host Long Non-Coding RNA during Viral Infection: Challenges and Paths Forward
Creator	Morrison, Juliet Peng, Xinxia Yang, Fang Rasmussen, Angela Harrell, Erin Lemler, David Brochu, Id, Hayden
topic	covid:27ee6e389b8f87a3545232db8b8fe385f73e5003#this
Source	Medline; PMC
abstract	Research over the past decade has clearly shown that long non-coding RNAs (lncRNAs) are functional. Many lncRNAs can be related to immunity and the host response to viral infection, but their specific functions remain largely elusive. The vast majority of lncRNAs are annotated with extremely limited knowledge and tend to be expressed at low levels, making ad hoc experimentation difficult. Changes to lncRNA expression during infection can be systematically profiled using deep sequencing; however, this often produces an intractable number of candidate lncRNAs, leaving no clear path forward. For these reasons, it is especially important to prioritize lncRNAs into high-confidence “hits” by utilizing multiple methodologies. Large scale perturbation studies may be used to screen lncRNAs involved in phenotypes of interest, such as resistance to viral infection. Single cell transcriptome sequencing quantifies cell-type specific lncRNAs that are less abundant in a mixture. When coupled with iterative experimental validations, new computational strategies for efficiently integrating orthogonal high-throughput data will likely be the driver for elucidating the functional role of lncRNAs during viral infection. This review highlights new high-throughput technologies and discusses the potential for integrative computational analysis to streamline the identification of infection-related lncRNAs and unveil novel targets for antiviral therapeutics.
has issue date	2017-10-20(xsd:dateTime)
bibo:doi	10.3390/vaccines5040037
bibo:pmid	29053596
has license	cc-by
sha1sum (hex)	27ee6e389b8f87a3545232db8b8fe385f73e5003
schema:url	https://doi.org/10.3390/vaccines5040037
resource representing a document's title	Elucidating the Role of Host Long Non-Coding RNA during Viral Infection: Challenges and Paths Forward
has PubMed Central identifier	PMC5748604
has PubMed identifier	29053596
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:27ee6e389b8f87a3545232db8b8fe385f73e5003#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/27ee6e389b8f87a3545232db8b8fe385f73e5003
is schema:about of	named entity 'THEIR' named entity 'REASONS' named entity 'COMPUTATIONAL ANALYSIS' named entity 'MAJORITY' named entity 'CLEAR' named entity 'TECHNOLOGIES' named entity 'LONG NON-CODING RNAS' named entity 'TEND' named entity 'KNOWLEDGE' named entity 'MIXTURE' named entity 'TARGETS' named entity 'FUNCTIONS' named entity 'DIFFICULT' named entity 'STRATEGIES' named entity 'OF INTEREST' named entity 'EXPRESSED' named entity 'USED' named entity 'PHENOTYPES' named entity 'ANTIVIRAL' named entity 'TYPE' named entity 'INTRACTABLE' named entity 'THROUGHPUT' named entity 'targets' named entity 'perturbation' named entity 'intractable' named entity 'functional' named entity 'sequencing' named entity 'high-throughput' named entity 'expression' named entity 'infection' named entity 'expressed' named entity 'functional' named entity 'functions' named entity 'number' named entity 'profiled' named entity 'deep sequencing' named entity 'The' named entity 'vaccines' named entity 'HOST' named entity 'VIRAL INFECTION' named entity 'EXTREMELY LIMITED' named entity 'LIKELY' named entity 'LEVELS' named entity 'COMPUTATIONAL' named entity 'IDENTIFICATION' named entity 'EXPRESSION' named entity 'FORWARD' named entity 'ANNOTATED' named entity 'ORTHOGONAL' named entity 'DEEP SEQUENCING' named entity 'PATH' named entity 'COUPLED' named entity 'MAY BE' named entity 'VIRAL INFECTION' named entity 'RESPONSE TO' named entity 'LARGELY' named entity 'STUDIES' named entity 'METHODOLOGIES' named entity 'VACCINES' named entity 'CHALLENGES' named entity 'FORWARD' named entity 'ROLE' named entity 'LONG NON-CODING RNA' named entity 'SINGLE CELL TRANSCRIPTOME SEQUENCING' named entity 'REVIEW' named entity 'SPECIFIC' named entity 'EXPERIMENTAL' named entity 'NEW' named entity 'DRIVER' named entity 'RESISTANCE TO' named entity 'PAST' named entity 'NUMBER OF'

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