About: Expression profile and histological distribution of IFITM1 and IFITM3 during H9N2 avian influenza virus infection in BALB/c mice

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About: Expression profile and histological distribution of IFITM1 and IFITM3 during H9N2 avian influenza virus infection in BALB/c mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Expression profile and histological distribution of IFITM1 and IFITM3 during H9N2 avian influenza virus infection in BALB/c mice
Creator	Liao, Ming Qi, Wenbao Yu, Meng Ning, Zhangyong Huang, Zhiqiang Liu, Rongchang Ye, Jinhui Zhang, Kaizhao Heng, · Yongjiang, Wang
source	Medline; PMC
abstract	The H9N2 avian influenza virus is a pandemic threat which has repeatedly caused infection in humans and shows enhanced replication and transmission in mice. Previous reports showed that host factors, the interferon-inducible transmembrane (IFITM) protein, can block the replication of pathogens and affect their pathogenesis. BALB/c mice are routine laboratory animals used in influenza virus research, but the effects of H9N2 influenza virus on tissue distribution and expression pattern of IFITM in these mice are unknown. Here, we investigated the expression patterns and tissue distribution of IFITM1 and IFITM3 in BALB/c mice by infection with H9N2 AIV strains with only a PB2 residue 627 difference. The results showed that the expression patterns of ITITM1 and IFITM3 differ in various tissues of BALB/c mice at different time points after infection. IFITM1 and IFITM3 showed cell- and tissue-specific distribution in the lung, heart, liver, spleen, kidney and brain. Notably, the epithelial and neuronal cells all expressed the proteins of IFITM1 and IFITM3. Our results provide the first look at differences in IFITM1 and IFITM3 expression patterns in BALB/c mice infected by H9N2 influenza viruses. This will enhance research on the interaction between AIV and host and further will elucidate the pathogenesis of influenza virus infection based on the interferon-inducible transmembrane (IFITM) protein. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00430-014-0361-2) contains supplementary material, which is available to authorized users.
has issue date	2014-09-30(xsd:dateTime)
bibo:doi	10.1007/s00430-014-0361-2
bibo:pmid	25265877
has license	no-cc
sha1sum (hex)	281c899ec67bd44f67476bf76e9b8df3cfe729e2
schema:url	https://doi.org/10.1007/s00430-014-0361-2
resource representing a document's title	Expression profile and histological distribution of IFITM1 and IFITM3 during H9N2 avian influenza virus infection in BALB/c mice
has PubMed Central identifier	PMC7087031
has PubMed identifier	25265877
schema:publication	Med Microbiol Immunol
resource representing a document's body	covid:281c899ec67bd44f67476bf76e9b8df3cfe729e2#body_text
is schema:about of	named entity 'Expression' named entity 'distribution' named entity 'avian influenza' named entity 'DISTRIBUTION' named entity 'HISTOLOGICAL' named entity 'EXPRESSION PROFILE' named entity 'BALB' named entity 'MICE' named entity 'AVIAN INFLUENZA VIRUS' named entity 'VIRUS INFECTION' named entity 'IFITM3' named entity 'IFITM1' named entity 'mice' named entity 'Expression profile' named entity '0.01' named entity 'influenza virus' named entity 'IFITM1' named entity 'IFITM1' named entity 'infection' named entity 'control group' named entity 'H7N9' named entity 'H9N2' named entity 'endosomal' named entity 'IFITM3' named entity 'influenza virus' named entity 'pathogenesis' named entity 'IFITM3' named entity 'infection' named entity 'China' named entity 'IFITM3' named entity 'statistically significant' named entity 'IFITM3' named entity 'muscle cells' named entity 'pathogen' named entity 'lymphocytes' named entity 'viruses' named entity 'influenza virus' named entity 'China' named entity '0.01' named entity 'seroprevalence' named entity 'tissue-specific expression' named entity 'infection' named entity 'IFITM3' named entity 'influenza virus' named entity 'H9N2' named entity 'virus' named entity 'immunohistochemical' named entity 'expression patterns' named entity 'lung' named entity 'infection' named entity 'AIV' named entity 'infection' named entity 'statistical analysis' named entity 'IFITM3' named entity 'IFITM3' named entity 'epithelial cells' named entity '3,5' named entity 'liver' named entity 'statistical analysis' named entity 'PBS' named entity 'IFITM3' named entity 'lungs' named entity 'IFITM1' named entity 'bronchioles' named entity 'infection' named entity 'IFITM3' named entity 'IFITM3' named entity 'IFITM3' named entity 'IFITM1' named entity 'statistical analysis' named entity 'IFITM1' named entity 'IFITM1'

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