About: Pneumonic vs Nonpneumonic Acute Exacerbations of COPD

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pneumonic vs Nonpneumonic Acute Exacerbations of COPD
Creator	Dvoskin, Bella Leinonen, Maija Lieberman, David Lieberman, Devora Gelfer, Yevgenia Varshavsky, Raiesa Friedman, Maureen
Source	Elsevier; Medline; PMC
abstract	Study objective To describe and compare the background, clinical manifestations, disease course, and infectious etiologies of pneumonic acute exacerbations (PNAE) vs nonpneumonic acute exacerbations (NPAE) of COPD. Design A prospective, observational study. Setting A tertiary university medical center in southern Israel. Patients Twenty-three hospitalizations for PNAE and 217 hospitalizations for NPAE were included in the study. Paired sera were obtained for each of the hospitalizations and were tested serologically for 12 pathogens. Only a significant change in antibody titers or levels was considered diagnostic. Results No significant differences were found between the two groups for any of the parameters related to COPD or comorbidity. The clinical type of the exacerbation was not significantly different between the groups. Compared to NPAE, patients with PNAE had lower Po 2 values at hospital admission (p = 0.004) but higher rates of abrupt onset (p = 0.005), ICU admissions (p = 0.006), invasive mechanical ventilation (p = 0.01), mortality (p = 0.007), and longer hospital stay (p = 0.001). In 22 PNAE hospitalizations (96%) and in 153 NPAE hospitalizations (71%), at least one infectious etiology was identified (p = 0.001). Mixed infection was found in 13 patients with PNAE (59%) and in 59 patients with NPAE (39%; not significant [NS]). Viral etiology was identified in 18 patients with PNAE (78%) compared with 99 patients with NPAE (46%; p = 0.003). Pneumococcal etiology was found in 10 patients with PNAE (43%) and in 38 patients with NPAE (18%; p = 0.006). An atypical etiology was identified in 8 patients with PNAE (35%) and 64 patients with NPAE (30%; NS). Conclusions Community-acquired pneumonia is common among patients hospitalized for an acute exacerbation of COPD and is generally manifested by more severe clinical and laboratory parameters. In PNAE, compared to NPAE, viral and pneumococcal etiologies are more common, but the rate of atypical pathogens is similar. The therapeutic significance of these findings should be investigated further.
has issue date	2002-10-31(xsd:dateTime)
bibo:doi	10.1378/chest.122.4.1264
bibo:pmid	12377851
has license	els-covid
sha1sum (hex)	2942c5a1038a931a7366ed100b49b6df7188435f
schema:url	https://doi.org/10.1378/chest.122.4.1264
resource representing a document's title	Pneumonic vs Nonpneumonic Acute Exacerbations of COPD
has PubMed Central identifier	PMC7094389
has PubMed identifier	12377851
schema:publication	Chest
resource representing a document's body	covid:2942c5a1038a931a7366ed100b49b6df7188435f#body_text
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