About: Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea

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About: Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea
Creator	Cho, Kyoung-Oh Park, Sang-Ik Park, Su-Jin Jeong, Young-Ju Kim, Hyun-Jeong Kim, Deok-Song Kwon, Hyung-Jun Lee, Ju-Hwan Park, Jun-Gyu Ryu, Eun-Hye Son, Kyu-Yeol Hosmillo, Myra Kim, Ji-Yun Alfajaro, Mia Lee, Woo Ryu, Young
Source	Medline; PMC
abstract	BACKGROUND: Since rotavirus is one of the leading pathogens that cause severe gastroenteritis and represents a serious threat to human and animal health, researchers have been searching for cheap, safe, and effective anti-rotaviral drugs. There is a widespread of interest in using natural products as antiviral agents, and among them, licorice derived from Glycyrrhiza spp. has exerted antiviral properties against several viruses. In this study, anti-rotaviral efficacy of Glycyrrhiza uralensis extract (GUE) as an effective and cheaper remedy without side-effects was evaluated in colostrums-deprived piglets after induction of rotavirus diarrhea. METHODS: Colostrums-deprived piglets were inoculated with porcine rotavirus K85 (G5P[7]) strain. On the onset of diarrhea, piglets were treated with different concentration of GUE. To evaluate the antiviral efficacy of GUE, fecal consistency score, fecal virus shedding and histological changes of the small intestine, mRNA expression levels of inflammation-related cytokines (IL8, IL10, IFN-β, IFN-γ and TNF-α), signaling molecules (p38 and JNK), and transcription factor (NFκB) in the small intestine and spleen were determined. RESULTS: Among the dosages (100-400 mg/ml) administrated to animals, 400 mg/ml of GUE cured diarrhea, and markedly improved small intestinal lesion score and fecal virus shedding. mRNA expression levels of inflammation-related cytokines (IL8, IL10, IFN-β, IFN-γ and TNF-α), signaling molecules (p38 and JNK), and transcription factor (NFκB) in the small intestine and spleen were markedly increased in animals with RVA-induced diarrhea, but dose- dependently decreased in GUE treated animals after RVA-induced diarrhea. CONCLUSIONS: GUE cures rotaviral enteritis by coordinating antiviral and anti-inflammatory effects. Therapy of this herbal medicine can be a viable medication for curing rotaviral enteritis in animals and humans.
has issue date	2012-12-18(xsd:dateTime)
bibo:doi	10.1186/1743-422x-9-310
bibo:pmid	23244491
has license	cc-by
sha1sum (hex)	29da5f5d00af5c47f9b3a0a49d561f8caffb0cf3
schema:url	https://doi.org/10.1186/1743-422x-9-310
resource representing a document's title	Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea
has PubMed Central identifier	PMC3547719
has PubMed identifier	23244491
schema:publication	Virol J
resource representing a document's body	covid:29da5f5d00af5c47f9b3a0a49d561f8caffb0cf3#body_text
is schema:about of	named entity 'DIARRHEA' named entity 'natural products' named entity 'TNF-α' named entity 'evaluate' named entity 'piglets' named entity 'ROTAVIRAL' named entity 'SAFE' named entity 'EFFECTIVE' named entity 'PATHOGENS' named entity 'IL10' named entity 'THREAT' named entity 'INFLAMMATION' named entity 'FECAL' named entity 'EFFICACY' named entity 'IS A' named entity 'ROTAVIRAL' named entity 'MRNA EXPRESSION' covid:arg/29da5f5d00af5c47f9b3a0a49d561f8caffb0cf3 named entity 'RELATED' named entity 'DIARRHEA' named entity 'DIFFERENT' named entity 'ROTAVIRUS' named entity 'GLYCYRRHIZA URALENSIS EXTRACT' named entity 'STRAIN' named entity 'ANTIVIRAL' named entity 'PORCINE ROTAVIRUS' named entity 'ROTAVIRUS' named entity 'EFFECTS' named entity 'K85' named entity 'HISTOLOGICAL' named entity 'WIDESPREAD' named entity 'TRANSCRIPTION FACTOR' named entity 'LEVELS' named entity 'TREATED WITH' named entity 'NATURAL PRODUCTS' named entity 'HAVE' named entity 'ANIMAL HEALTH' named entity 'HUMAN' named entity 'CHANGES' named entity 'COLOSTRUMS' named entity 'SCORE' named entity 'GASTROENTERITIS' named entity 'RESEARCHERS' named entity 'SPLEEN' named entity 'DERIVED' named entity 'SEVERE' named entity 'ONSET OF' named entity 'GLYCYRRHIZA URALENSIS EXTRACT' named entity 'IFN' named entity 'INDUCTION' named entity 'JNK' named entity 'STUDY' named entity 'REMEDY' named entity 'METHODS' named entity 'EXERTED' named entity 'SIGNALING MOLECULES' named entity 'DETERMINED' named entity 'USING' named entity 'LICORICE' named entity 'BAB' named entity 'EFFECTS' named entity 'BACKGROUND' named entity 'SMALL INTESTINE' named entity 'CONSISTENCY' named entity 'ANTIVIRAL AGENTS' named entity 'ONE OF'

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