About: A Single and Un-Adjuvanted Dose of a Chimpanzee Adenovirus-Vectored Vaccine against Chikungunya Virus Fully Protects Mice from Lethal Disease

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About: A Single and Un-Adjuvanted Dose of a Chimpanzee Adenovirus-Vectored Vaccine against Chikungunya Virus Fully Protects Mice from Lethal Disease Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Single and Un-Adjuvanted Dose of a Chimpanzee Adenovirus-Vectored Vaccine against Chikungunya Virus Fully Protects Mice from Lethal Disease
Creator	Reyes-Sandoval, Arturo Lopez-Camacho, Cesar Preciado-Llanes, Lorena Rossi, Shannan Azar, Sasha Campos, Rafael
Source	PMC
abstract	The mosquito-borne chikungunya virus (CHIKV) has become a major global health problem. Upon infection, chikungunya fever (CHIKF) can result in long-term joint pain and arthritis, and despite intense research, no licensed vaccine for CHIKV is available. We have developed two recombinant chimpanzee adenovirus-vectored vaccines (ChAdOx1) that induce swift and robust anti-CHIKV immune responses with a single dose, without the need for adjuvants or booster vaccines. Here, we report the vaccines’ protective efficacies against CHIKV infection in a lethal A129 mouse model. Our results indicate that a single, un-adjuvanted ChAdOx1 Chik or ChAdOx1 Chik ΔCap dose provided complete protection against a lethal virus challenge and prevented CHIKV-associated severe inflammation. These candidate vaccines supported survival equal to the attenuated 181/25 CHIKV reference vaccine but without the vaccine-related side effects, such as weight loss. Vaccination with either ChAdOx1 Chik or ChAdOx1 Chik ΔCap resulted in high titers of neutralizing antibodies that are associated with protection, indicating that the presence of the capsid within the vaccine construct may not be essential to afford protection under the conditions tested. We conclude that both replication-deficient ChAdOx1 Chik vaccines are safe even when used in A129 mice and afford complete protection from a lethal challenge.
has issue date	2019-11-12(xsd:dateTime)
bibo:doi	10.3390/pathogens8040231
bibo:pmid	31718104
has license	cc-by
sha1sum (hex)	29ffe6751373335a54c9d02cec1af4cfdf049ea8
schema:url	https://doi.org/10.3390/pathogens8040231
resource representing a document's title	A Single and Un-Adjuvanted Dose of a Chimpanzee Adenovirus-Vectored Vaccine against Chikungunya Virus Fully Protects Mice from Lethal Disease
has PubMed Central identifier	PMC6963200
has PubMed identifier	31718104
schema:publication	Pathogens
resource representing a document's body	covid:29ffe6751373335a54c9d02cec1af4cfdf049ea8#body_text
is schema:about of	named entity 'survival' named entity 'global health' named entity 'Our' named entity 'vaccines' named entity 'equal' named entity 'Disease' named entity 'Virus' named entity 'MICE' named entity 'CHIKUNGUNYA VIRUS' named entity 'HAVE' named entity 'IMMUNE RESPONSES' named entity 'SWIFT' named entity 'SURVIVAL' named entity 'ADJUVANTED' named entity 'RELATED' named entity 'WEIGHT LOSS' named entity 'EITHER' named entity 'SAFE' named entity 'CHIKUNGUNYA VIRUS' named entity 'REFERENCE' named entity 'VECTORED' named entity 'LICENSED VACCINE' named entity 'INFECTION' named entity 'COMPLETE' named entity 'BOOSTER' named entity 'BUT' named entity 'CHALLENGE' named entity 'AVAILABLE' named entity 'MOUSE MODEL' named entity 'ASSOCIATED WITH' named entity 'SINGLE' named entity 'DISEASE' named entity 'FULLY' named entity 'RESULTS' named entity 'CONSTRUCT' named entity 'ASSOCIATED' named entity 'CONDITIONS' named entity 'HIGH' named entity 'ATTENUATED' named entity 'NEED FOR' named entity 'CHIMPANZEE ADENOVIRUS' named entity 'LETHAL' named entity 'VACCINE' named entity 'VECTORED' named entity 'MOSQUITO' named entity 'CONCLUDE' named entity 'HEALTH PROBLEM' named entity 'PROVIDED' named entity 'CAPSID' named entity 'PROTECTION' named entity 'THESE' named entity 'ARTHRITIS' named entity 'LONG-TERM' named entity 'PRESENCE OF' named entity 'INTENSE' named entity 'DEFICIENT' named entity 'LETHAL' named entity 'VACCINATION' named entity 'SUPPORTED' named entity 'DOSE' named entity 'USED' named entity 'RESEARCH' named entity 'EQUAL TO' named entity 'VACCINES' named entity 'TESTED' named entity 'BORNE' named entity 'ESSENTIAL' named entity 'A MAJOR' named entity 'JOINT PAIN' named entity 'INDICATING' named entity 'SINGLE' named entity 'CANDIDATE' named entity 'SIDE EFFECTS' named entity 'CHIMPANZEE ADENOVIRUS' named entity 'SEVERE INFLAMMATION' named entity 'HERE'

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