About: Clinical Characteristics and Outcomes of Community- and Hospital-Acquired Acute Kidney Injury with COVID-19 in a US Inner City Hospital System

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About: Clinical Characteristics and Outcomes of Community- and Hospital-Acquired Acute Kidney Injury with COVID-19 in a US Inner City Hospital System Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical Characteristics and Outcomes of Community- and Hospital-Acquired Acute Kidney Injury with COVID-19 in a US Inner City Hospital System
Creator	Peterson, Eric Albano, Jeri Azmaiparashvili, Zurab Bhargav, Ruchika Gul, Fahad Lo, Bryan Pelayo, Jerald Rangaswami, Janani Salacup, Grace Dejoy, Robert Gopalakrishnan, Akshaya Patarroyo-Aponte, Gabriel
source	Medline; PMC
abstract	INTRODUCTION: Emerging data have described poor clinical outcomes from infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) among African American patients and those from underserved socioeconomic groups. We sought to describe the clinical characteristics and outcomes of acute kidney injury (AKI) in this special population. METHODS: This is a retrospective study conducted in an underserved area with a predominance of African American patients with coronavirus disease 2019 (COVID-19). Descriptive statistics were used to characterize the sample population. The onset of AKI and relation to clinical outcomes were determined. Multivariate logistic regression was used to determine factors associated with AKI. RESULTS: Nearly half (49.3%) of the patients with COVID-19 had AKI. Patients with AKI had a significantly lower baseline estimated glomerular filtration rate (eGFR) and higher FiO2 requirement and D-dimer levels on admission. More subnephrotic proteinuria and microhematuria was seen in these patients, and the majority had a pre-renal urine electrolyte profile. Patients with hospital-acquired AKI (HA-AKI) as opposed to those with community-acquired AKI (CA-AKI) had higher rates of in-hospital death (52 vs. 23%, p = 0.005), need for vasopressors (42 vs. 25%, p = 0.024), and need for intubation (55 vs. 25%, p = 0.006). A history of heart failure was significantly associated with AKI after adjusting for baseline eGFR (OR 3.382, 95% CI 1.121–13.231, p = 0.032). CONCLUSION: We report a high burden of AKI among underserved COVID-19 patients with multiple comorbidities. Those who had HA-AKI had worse clinical outcomes compared to those who with CA-AKI. A history of heart failure is an independent predictor of AKI in patients with COVID-19.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.1159/000509182
bibo:pmid	32554965
has license	no-cc
sha1sum (hex)	2a05e94254d0568cca2bfcea5cf1ae8d701872d8
schema:url	https://doi.org/10.1159/000509182
resource representing a document's title	Clinical Characteristics and Outcomes of Community- and Hospital-Acquired Acute Kidney Injury with COVID-19 in a US Inner City Hospital System
has PubMed Central identifier	PMC7360498
has PubMed identifier	32554965
schema:publication	Cardiorenal Med
resource representing a document's body	covid:2a05e94254d0568cca2bfcea5cf1ae8d701872d8#body_text
is schema:about of	named entity 'special' named entity 'higher' named entity 'electrolyte' named entity 'AKI' named entity 'conducted' named entity 'Outcomes' named entity 'City Hospital' named entity 'COVID-19' named entity 'PROTEINURIA' named entity 'GROUPS' named entity 'MULTIVARIATE LOGISTIC REGRESSION' named entity 'DETERMINED' named entity 'Introduction' named entity 'hospital-acquired' named entity 'Multivariate' named entity 'patients' named entity 'population' named entity 'SARS-CoV' named entity 'describe' named entity 'acute kidney injury' named entity 'higher' named entity 'Emerging' named entity 'Patients' named entity 'community-acquired' named entity 'Injury' named entity 'urine' named entity 'AKI' named entity 'vasopressors' named entity 'proteinuria' named entity 'AKI' named entity 'coronavirus disease 2019' named entity 'COVID' named entity 'pre-renal' named entity 'microhematuria' named entity 'socioeconomic groups' named entity 'eGFR' named entity 'infection' named entity 'AKI' named entity 'AKI' named entity 'African American' named entity 'China' named entity 'AKI' named entity 'ARBs' named entity 'hypertension' named entity 'AKI' named entity 'intubated' named entity 'COVID-19' named entity 'COVID' named entity 'AKI' named entity 'urine' named entity 'AKI' named entity 'comorbidities' named entity 'pathophysiologic mechanisms' named entity 'descriptive statistics' named entity 'AKI' named entity 'kidney' named entity 'AKI' named entity 'clinical outcomes' named entity 'AKI' named entity 'sample size' named entity 'vasopressor' named entity 'high-risk' named entity 'cytokine storm' named entity 'convalescent plasma therapy' named entity 'dialysis' named entity 'heart failure' named entity 'hypoxia' named entity 'COVID-19 disease' named entity 'myocarditis' named entity 'heart failure'

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