About: Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice
Creator	Fujishima, Yuya Fukuda, Shiro Kawachi, Yusuke Kita, Shunbun Maeda, Norikazu Miyagawa, Shigeru Nakamura, Yuto Nishida, Hiroyuki Nishizawa, Hitoshi Obata, Yoshinari Okita, Tomonori Sawa, Yoshiki Shimomura, Iichiro Takahashi, Yuki Takakura, Yoshinobu Tanaka, Yoshimitsu Tsugawa-Shimizu, Yuri
source	Elsevier; Medline; PMC
abstract	Mesenchymal stem/stromal cells (MSCs) are cultured adult stem cells that originally reside in virtually all tissues, and the gain of MSCs by transplantation has become the leading form of cell therapy in various diseases. However, there is limited knowledge on the alteration of its efficacy by factors in recipients. Here, we report that the cardioprotective properties of intravenously injected MSCs in a mouse model of pressure-overload heart failure largely depend on circulating adiponectin, an adipocyte-secreted factor. The injected MSCs exert their function through exosomes, extracellular vesicles of endosome origin. Adiponectin stimulated exosome biogenesis and secretion through binding to T-cadherin, a unique glycosylphosphatidylinositol-anchored cadherin, on MSCs. A pharmacological or adenovirus-mediated genetic increase in plasma adiponectin enhanced the therapeutic efficacy of MSCs. Our findings provide novel insights into the importance of adiponectin in mesenchymal-progenitor-mediated organ protections.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1016/j.ymthe.2020.06.026
bibo:pmid	32652045
has license	no-cc
sha1sum (hex)	2b207cdbe08b334571085f01e53cd0989a330a97
schema:url	https://doi.org/10.1016/j.ymthe.2020.06.026
resource representing a document's title	Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice
has PubMed Central identifier	PMC7351027
has PubMed identifier	32652045
schema:publication	Mol Ther
resource representing a document's body	covid:2b207cdbe08b334571085f01e53cd0989a330a97#body_text
is schema:about of	named entity 'MSCs' named entity 'efficacy' named entity 'Mesenchymal' named entity 'MESENCHYMAL' named entity 'DEPEND' named entity 'SECRETION' named entity 'LIMITED' named entity 'PROPERTIES' named entity 'PLASMA' named entity 'intravenously' named entity 'alteration' named entity 'genetic' named entity 'enhanced' named entity 'Exosome' named entity 'adult stem cells' named entity 'MSCs' named entity 'adiponectin' named entity 'adiponectin' named entity 'organ' named entity 'cadherin' named entity 'adenovirus' named entity 'MSCs' named entity 'MSCs' named entity 'heart failure' named entity 'adiponectin' named entity 'Mesenchymal stem/stromal cells' named entity 'Adiponectin' named entity 'Stem-Cell' named entity 'exosome' named entity 'MSCs' named entity 'one-way ANOVA' named entity 'agonist' named entity 'miRNA' named entity 'Adiponectin' named entity 'staining' named entity 'cardiac hypertrophy' named entity 'Echocardiography' named entity 'heart failure' named entity 'T-cadherin' named entity 'RNA-seq' named entity 'exosomes' named entity 'hematoxylin and eosin' named entity 'mice' named entity 'PPARg' named entity 'molecular level' named entity 'WCLs' named entity 'exosomes' named entity 'fibrin' named entity 'therapeutic effects' named entity 'Mesenchymal stem/stromal cells' named entity 'exosomes' named entity 'transfection' named entity 'agonist' named entity 'multimer' named entity 'Cytokine' named entity 'aorta' named entity 'membrane vesicles' named entity 'BNP' named entity 'MSCs' named entity 'transfected' named entity 'mice' named entity 'human adipose tissue' named entity 'adiponectin' named entity 'fetal' named entity 'fluorescent dye'

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