About: Molecular Insights into Poly(ADP-ribose) Recognition and Processing

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Insights into Poly(ADP-ribose) Recognition and Processing
Creator	Ahel, Ivan Barkauskaite, Eva Mikoč, Andreja
Source	Medline; PMC
abstract	Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis. The amount of poly(ADP-ribosyl)ation (PAR) in cells reflects the balance of synthesis, mediated by the PARP protein family, and degradation, which is catalyzed by a glycohydrolase, PARG. Many of the proteins mediating PAR metabolism possess specialised high affinity PAR-binding modules that allow the efficient sensing or processing of the PAR signal. The identification of four such PAR-binding modules and the characterization of a number of proteins utilising these elements during the last decade has provided important insights into how PAR regulates different cellular activities. The macrodomain represents a unique PAR-binding module which is, in some instances, known to possess enzymatic activity on ADP-ribose derivatives (in addition to PAR-binding). The most recently discovered example for this is the PARG protein, and several available PARG structures have provided an understanding into how the PARG macrodomain evolved into a major enzyme that maintains PAR homeostasis in living cells.
has issue date	2012-12-21(xsd:dateTime)
bibo:doi	10.3390/biom3010001
bibo:pmid	24970154
has license	cc-by
sha1sum (hex)	2bf9a03995b1056dc5d3e353461d3a31a9348885
schema:url	https://doi.org/10.3390/biom3010001
resource representing a document's title	Molecular Insights into Poly(ADP-ribose) Recognition and Processing
has PubMed Central identifier	PMC4030884
has PubMed identifier	24970154
schema:publication	Biomolecules
resource representing a document's body	covid:2bf9a03995b1056dc5d3e353461d3a31a9348885#body_text
is schema:about of	named entity 'POLY' named entity 'INSIGHTS' named entity 'post-translational' named entity 'evolved' named entity 'balance' named entity 'ADP-ribose' named entity 'possess' named entity 'affinity' named entity 'regulation' named entity 'Insights' named entity 'MOLECULAR' named entity 'CELLS' named entity 'IS A' named entity 'BINDING' named entity 'PAR' named entity 'POSSESS' named entity 'AFFINITY' named entity 'PROTEINS' named entity 'AVAILABLE' named entity 'KNOWN' named entity 'SIGNAL' named entity 'ALLOW' named entity 'MEDIATING' named entity 'SPECIALISED' named entity 'LIVING' named entity 'ELEMENTS' named entity 'ACTIVITIES' named entity 'PARG' named entity 'PROVIDED' named entity 'PROTEIN FAMILY' named entity 'CELLULAR' named entity 'ENZYMATIC ACTIVITY' named entity 'FUNCTIONS' named entity 'RIBOSYL' named entity 'EFFICIENT' named entity 'HIGH' named entity 'MITOSIS' named entity 'DIFFERENT' named entity 'EXAMPLE' named entity 'INVOLVED' named entity 'HOMEOSTASIS' named entity 'BALANCE' named entity 'POLY' named entity 'SENSING' named entity 'INSIGHTS' named entity 'UNIQUE' named entity 'ADP' named entity 'PROTEIN' named entity 'DEGRADATION' named entity 'MEDIATED' named entity 'RIBOSE' named entity 'TRANSCRIPTION' named entity 'A MAJOR' named entity 'CHARACTERIZATION' named entity 'ADDITION' named entity 'IDENTIFICATION' named entity 'REGULATION' named entity 'PARP' named entity 'REFLECTS' named entity 'HAVE' named entity 'INCLUDING' named entity 'ENZYME' named entity 'STRUCTURES' named entity 'NUMBER OF' named entity 'UNDERSTANDING' named entity 'DNA REPAIR' named entity 'HOW' named entity 'RECENTLY' named entity 'METABOLISM ' named entity 'EVOLVED' named entity 'APOPTOSIS' named entity 'MODULE' named entity 'DECADE' named entity 'RECOGNITION' named entity 'PROCESSING' named entity 'RIBOSE DERIVATIVES' named entity 'POST-TRANSLATIONAL PROTEIN MODIFICATION' named entity 'SYNTHESIS' named entity 'IMPORTANT'

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