About: Identification of Three Antiviral Inhibitors against Japanese Encephalitis Virus from Library of Pharmacologically Active Compounds 1280

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About: Identification of Three Antiviral Inhibitors against Japanese Encephalitis Virus from Library of Pharmacologically Active Compounds 1280 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of Three Antiviral Inhibitors against Japanese Encephalitis Virus from Library of Pharmacologically Active Compounds 1280
Creator	Sun, L Xu, J Fang, J Peng, G Zhou, R
source	PMC
abstract	Japanese encephalitis virus (JEV) can cause severe central nervous disease with a high mortality rate. There is no antiviral drug available for JEV-specific treatment. In this study, a cytopathic-effect-based, high-throughput screening assay was developed and applied to screen JEV inhibitors from Library of Pharmacologically Active Compounds 1280. The antiviral effects of three hit compounds including FGIN-1-27, cilnidipine, and niclosamide were evaluated in cells by western blotting, indirect immunofluorescence assay, and plaque reduction assay. A time-of-addition assay proved that all three compounds inhibited JEV at the stage of replication. The EC50s of FGIN-1-27, cilnidipine, and niclosamide were 3.21, 6.52, and 5.80 µM, respectively, while the selectivity indexes were 38.79, 30.67, and 7.49. FGIN-1-27 and cilnidipine have high efficiency and selectivity against JEV. This study provided two JEV antiviral inhibitors as candidates for treatment of JEV infection.
has issue date	2013-11-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0078425
bibo:pmid	24348901
has license	cc-by
sha1sum (hex)	2c5983eedfe4431e007a45dcf0103176ed1d9ff8
schema:url	https://doi.org/10.1371/journal.pone.0078425
resource representing a document's title	Identification of Three Antiviral Inhibitors against Japanese Encephalitis Virus from Library of Pharmacologically Active Compounds 1280
has PubMed Central identifier	PMC3857149
has PubMed identifier	24348901
schema:publication	PLoS One
resource representing a document's body	covid:2c5983eedfe4431e007a45dcf0103176ed1d9ff8#body_text
is schema:about of	named entity 'developed' named entity 'JEV' named entity 'antiviral' named entity 'high' named entity 'compounds' named entity 'reduction' named entity 'effects' named entity 'evaluated' named entity '1280' named entity 'FGIN-1-27' named entity 'LIBRARY' named entity 'INCLUDING' named entity 'INHIBITORS' named entity 'REPLICATION' named entity 'SEVERE' named entity 'SCREEN' named entity 'PLAQUE' named entity 'WESTERN BLOTTING' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'STUDY' named entity 'ANTIVIRAL' named entity 'BASED' named entity 'TREATMENT' named entity 'REDUCTION' named entity 'INDEXES' named entity 'CILNIDIPINE' named entity 'OF-' named entity 'ADDITION' named entity 'PROVIDED' named entity '1280' named entity 'ASSAY' named entity 'ANTIVIRAL' named entity 'INDIRECT IMMUNOFLUORESCENCE' named entity 'IDENTIFICATION' named entity 'NICLOSAMIDE' named entity 'DRUG AVAILABLE' named entity 'HIGH EFFICIENCY' named entity 'STAGE' named entity 'EFFECT' named entity 'HIGH' named entity 'MORTALITY RATE' named entity 'CAUSE' named entity 'HAVE' named entity 'TIME' named entity 'INHIBITORS' named entity 'ACTIVE' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'HIT' named entity 'HIGH-THROUGHPUT SCREENING' named entity 'ACTIVE' named entity 'CELLS' named entity 'APPLIED' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'SPECIFIC' named entity 'SELECTIVITY' named entity 'LIBRARY' named entity 'INFECTION' named entity 'ANTIVIRAL DRUG' named entity 'INHIBITED' named entity 'EVALUATED' named entity 'CENTRAL NERVOUS DISEASE' covid:arg/2c5983eedfe4431e007a45dcf0103176ed1d9ff8 named entity 'niclosamide' named entity 'This' named entity 'western blotting' named entity 'candidates' named entity 'assay' named entity 'JEV' named entity 'central' named entity 'Japanese Encephalitis Virus' named entity 'Pharmacologically Active Compounds' named entity 'Japanese encephalitis' named entity 'assay' named entity 'antiviral inhibitors' named entity 'JEV' named entity 'mortality rate' named entity 'niclosamide'

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