About: Reduced dynamic range of antiviral innate immune responses in aging

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reduced dynamic range of antiviral innate immune responses in aging
Creator	Malawista, Anna Montgomery, Ruth Molony, Ryan
Source	Elsevier; Medline; PMC
abstract	The worldwide population aged ≥65 years is increasing and the average life span is expected to increase another 10 years by 2050. This extended lifespan is associated with a progressive decline in immune function and a paradoxical state of low-grade, chronic inflammation that may contribute to susceptibility to viral infection, and reduced responses to vaccination. Here we review the effects of aging on innate immune responses to viral pathogens including elements of recognition, signaling, and production of inflammatory mediators. We specifically focus on age-related changes in key pattern recognition receptor signaling pathways, converging on altered cytokine responses with age, including a notable impairment of antiviral interferon responses. We highlight an emergent change in innate immunity that arises during aging –the dampening of the dynamic range of responses to multiple sources of stimulation – which may underlie reduced efficiency of immune responses in aging.
has issue date	2018-07-01(xsd:dateTime)
bibo:doi	10.1016/j.exger.2017.08.019
bibo:pmid	28822811
has license	green-oa
sha1sum (hex)	2d5745abc30fbf8c050d4b68278ac8d6fe00bb90
schema:url	https://doi.org/10.1016/j.exger.2017.08.019
resource representing a document's title	Reduced dynamic range of antiviral innate immune responses in aging
has PubMed Central identifier	PMC5815956
has PubMed identifier	28822811
schema:publication	Experimental Gerontology
resource representing a document's body	covid:2d5745abc30fbf8c050d4b68278ac8d6fe00bb90#body_text
is schema:about of	named entity 'IMMUNE RESPONSES' named entity 'immune responses' named entity 'antiviral' named entity 'AGING' named entity 'NOTABLE' named entity 'WORLDWIDE' named entity 'ANTIVIRAL' named entity 'AGED' named entity 'HERE' named entity 'PROGRESSIVE DECLINE' named entity 'KEY' named entity 'EFFECTS' named entity 'INFLAMMATORY MEDIATORS' named entity 'CHANGE IN' named entity 'SIGNALING PATHWAYS' named entity 'ASSOCIATED WITH' named entity 'EMERGENT' named entity 'SUSCEPTIBILITY TO VIRAL INFECTION' named entity 'POPULATION' named entity 'YEARS' named entity 'REDUCED' named entity 'RESPONSES' named entity 'ALTERED' named entity 'SOURCES' named entity 'INCLUDING' named entity 'INTERFERON ' named entity 'DYNAMIC RANGE' named entity 'DYNAMIC RANGE' named entity 'VIRAL PATHOGENS' named entity 'FOCUS' named entity 'REDUCED' named entity 'AVERAGE LIFE SPAN' named entity 'REVIEW' named entity 'PARADOXICAL' named entity 'INNATE IMMUNITY' named entity 'INCREASING' named entity 'RECOGNITION' named entity 'CONTRIBUTE ' named entity 'EXTENDED LIFESPAN' named entity 'IMPAIRMENT' named entity 'ANTIVIRAL' named entity 'AGE' named entity 'CONVERGING' named entity 'EFFICIENCY' named entity 'CHANGES' named entity 'GRADE' named entity 'IMMUNE RESPONSES' named entity 'MULTIPLE' named entity 'SIGNALING' named entity 'TO INCREASE' named entity 'ELEMENTS' named entity 'EXPECTED' named entity 'IMMUNE FUNCTION' named entity 'STATE' named entity 'VACCINATION' named entity 'PATTERN RECOGNITION RECEPTOR' named entity 'CYTOKINE ' named entity 'LOW' named entity 'PRODUCTION' named entity 'CHRONIC INFLAMMATION' named entity 'RECEPTOR SIGNALING' named entity 'AGING' named entity 'RELATED' covid:arg/2d5745abc30fbf8c050d4b68278ac8d6fe00bb90 named entity 'life' named entity 'emergent' named entity 'expected' named entity 'viral pathogens' named entity 'reduced' named entity 'focus' named entity 'innate immune responses' named entity 'pattern recognition receptor' named entity '10 years' named entity 'production' named entity 'viral infection' named entity 'extended lifespan' named entity 'innate immune responses' named entity 'responses' named entity 'immune function'

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