About: LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD4(+) and CD8(+)) as well as a reduction of parasitism after challenge with Leishmania infantum plus salivary gland of Lutzomyia longipalpis

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About: LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD4(+) and CD8(+)) as well as a reduction of parasitism after challenge with Leishmania infantum plus salivary gland of Lutzomyia longipalpis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD4(+) and CD8(+)) as well as a reduction of parasitism after challenge with Leishmania infantum plus salivary gland of Lutzomyia longipalpis
Creator	Corrêa-Oliveira, Rodrigo Teixeira-Carvalho, Andréa Bruna-Romero, Oscar Aguiar-Soares, Oliveira Assis Martins-Filho, Olindo Augusto, Fernando Das, Nádia Dian, Rodrigo Giunchetti, Rodolfo Mendes Roatt, Bruno Moreira, Dores Reis, Alexandre Figueiredo Gontijo, Nelder Ker, Henrique Mathias, Siqueira Mirelle De Oliveira Cardoso, Jamille
Source	Medline; PMC
abstract	BACKGROUND: The development of a protective vaccine against canine visceral leishmaniasis (CVL) is an alternative approach for interrupting the domestic cycle of Leishmania infantum. Given the importance of sand fly salivary proteins as potent immunogens obligatorily co-deposited during transmission of Leishmania parasites, their inclusion in an anti-Leishmania vaccine has been investigated in the last few decades. In this context, we previously immunized dogs with a vaccine composed of L. braziliensis antigens plus saponin as the adjuvant and sand fly salivary gland extract (LBSapSal vaccine). This vaccine elicited an increase in both anti-saliva and anti-Leishmania IgG isotypes, higher counts of specific circulating CD8(+) T cells, and high NO production. METHODS: We investigated the immunogenicity and protective effect of LBSapSal vaccination after intradermal challenge with 1 × 10(7) late-log-phase L. infantum promastigotes in the presence of sand fly saliva of Lutzomyia longipalpis. The dogs were followed for up to 885 days after challenge. RESULTS: The LBSapSal vaccine presents extensive antigenic diversity with persistent humoral and cellular immune responses, indicating resistance against CVL is triggered by high levels of total IgG and its subtypes (IgG1 and IgG2); expansion of circulating CD5(+), CD4(+), and CD8(+) T lymphocytes and is Leishmania-specific; and reduction of splenic parasite load. CONCLUSIONS: These results encourage further study of vaccine strategies addressing Leishmania antigens in combination with proteins present in the saliva of the vector.
has issue date	2014-02-07(xsd:dateTime)
bibo:doi	10.1186/1756-3305-7-61
bibo:pmid	24507702
has license	cc-by
sha1sum (hex)	2e83f16bbbc37d4cf2eba3dd0479e4ec7da6fc41
schema:url	https://doi.org/10.1186/1756-3305-7-61
resource representing a document's title	LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD4(+) and CD8(+)) as well as a reduction of parasitism after challenge with Leishmania infantum plus salivary gland of Lutzomyia longipalpis
has PubMed Central identifier	PMC3943450
has PubMed identifier	24507702
schema:publication	Parasit Vectors
resource representing a document's body	covid:2e83f16bbbc37d4cf2eba3dd0479e4ec7da6fc41#body_text
is schema:about of	named entity 'salivary gland' named entity 'Leishmania' named entity 'context' named entity 'vaccine' named entity 'alternative' covid:arg/2e83f16bbbc37d4cf2eba3dd0479e4ec7da6fc41 named entity 'development' named entity 'investigated' named entity 'composed' named entity 'IgG' named entity 'isotypes' named entity 'Leishmania' named entity 'Leishmania infantum' named entity 'T-lymphocyte subsets' named entity 'serum samples' named entity 'Universidade Federal de Ouro Preto' named entity 'CD4' named entity 'vaccine' named entity 'monoclonal antibodies' named entity 'antigens' named entity 'parainfluenza' named entity 'supernatant' named entity 'Montgomery, TX' named entity 'Helsinki' named entity 'immunoglobulin isotypes' named entity 'promastigotes' named entity 'canine' named entity 'IgG1' named entity 'Incubation' named entity 'adjuvant' named entity 'polyclonal antibody' named entity 'BCG' named entity 'phlebotomines' named entity 'L. infantum' named entity 'lymphocytes' named entity 'homology' named entity 'vaccination of dogs' named entity 'IgG2' named entity 'IgG1' named entity 'high levels' named entity 'vector' named entity 'amastigotes' named entity 'L. infantum' named entity 'dog' named entity 'L. infantum' named entity 'CD8 +' named entity 'UFOP' named entity 'parasite' named entity 'protein' named entity 'follow-up' named entity 'PBMCs' named entity 'CD8' named entity 'Sand fly' named entity 'vaccine' named entity 'denaturation' named entity 'PCR' named entity 'RPMI' named entity 'salivary glands' named entity 'CD4' named entity 'Taufkirchen' named entity 'interleukin-12' named entity 'parasite' named entity 'visceral leishmaniasis' named entity 'intravenous' named entity 'lymphocytes' named entity 'infection'

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