About: Evaluation of convalescent whole blood for treating Ebola Virus Disease in Freetown, Sierra Leone

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evaluation of convalescent whole blood for treating Ebola Virus Disease in Freetown, Sierra Leone
Creator	Baker, S Abiri, O Ansumana, R Conton, B Gevao, S Goba, A Idriss, B Johnson, W Kamara, P Kargbo, O Lamin, J Massaquoi, T Nicol, S Russell, J Sahr, F Sesay, F
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Convalescent blood therapy has been a promising form of treatment for Ebola Virus Disease (EVD), but less attention has been focused on it for treatment. METHOD: We assessed the effectiveness of convalescent whole blood (CWB) in the treatment of consented EVD patients. We recruited 69 subjects in December 2014 up to April 2015, at the 34 Military Hospital in Wilberforce and the PTS 1 Ebola Treatment Unit in Hastings, Freetown. Forty-four were given CWB, and 25 who consented but preferred to be exempted from the CWB treatment were used to compare clinical outcomes. All were given routine treatment used at the Ebola Treatment Unit. RESULTS: One of 44 subjects treated with CWB dropped out of the study and 31 recovered while 12 succumbed to the disease with a case fatality rate of 27.9%. For the group that was given routine treatment without CWB, 11 died with a case fatality rate of 44%. There was a significant difference between admission viral load and viral load after the first 24 h of treatment with convalescent whole blood (P < 0.01). The odds ratio for survival with CWB was 2.3 (95% CI, 0.8–6.5). CONCLUSION: CWB is promising for treating EVD in resource-poor settings, especially in the early phases of outbreaks when resource-mobilization is done. Even though our sample size was small and the evaluation was not randomised, our results contribute to existing evidence that convalescent whole blood could be considered as a useful candidate for treating EVD. Further studies that are randomised will be required to further assess the efficacy of CWB as treatment option during any EVD outbreak.
has issue date	2016-11-17(xsd:dateTime)
bibo:doi	10.1016/j.jinf.2016.11.009
bibo:pmid	27867062
has license	no-cc
sha1sum (hex)	308a14bdcd431f299b90cd6b7ef1bff9897df2b2
schema:url	https://doi.org/10.1016/j.jinf.2016.11.009
resource representing a document's title	Evaluation of convalescent whole blood for treating Ebola Virus Disease in Freetown, Sierra Leone
has PubMed Central identifier	PMC7112610
has PubMed identifier	27867062
schema:publication	J Infect
resource representing a document's body	covid:308a14bdcd431f299b90cd6b7ef1bff9897df2b2#body_text
is schema:about of	named entity 'TREATING' named entity 'FREETOWN' named entity 'EVALUATION' named entity 'CONVALESCENT' named entity 'WHOLE BLOOD' named entity 'SIERRA LEONE' named entity 'EBOLA VIRUS DISEASE' named entity 'EVD' named entity 'control group' named entity 'IgG' named entity 'sore throat' named entity 'Korea' named entity 'analgesics' named entity 'syphilis' named entity 'supportive treatment' named entity 'blood bag' named entity 'recombinantly' named entity 'tablets' named entity 'case fatality rate' named entity 'Ministry of Health and Sanitation' named entity 'viral load' named entity 'animal-derived' named entity 'infectious agents' named entity 'antibiotics' named entity 'blood cells' named entity 'EVD' named entity 'plasma' named entity 'viral load' named entity 'organ dysfunction' named entity 'EVD' named entity 'HIV-1' named entity 'Freetown' named entity 'donated blood' named entity '95% CI' named entity 'reduced level of consciousness' named entity 'viral load' named entity 'antigens' named entity 'adverse reaction' named entity 'Matsudo' named entity 'transfusion' named entity 'fatality rate' named entity 'survival rate' named entity '7.5' named entity 'blood donors' named entity 'EVD' named entity 'EVD' named entity 'Eastern Sierra Leone' named entity '5.0' named entity 'Odds ratios' named entity 'risk of death' named entity 'Ebola' named entity 'viral load' named entity 'WHO' named entity 'standard deviations' named entity '0.01' named entity 'blood plasma' named entity 'Viral load' named entity 'rash' named entity '95% CI' named entity 'risk of death' named entity '95% CI' named entity 'plasma' named entity 'real-time PCR' named entity 'virus infection' named entity 'viral load' named entity 'viral load'

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