About: Evidence of potent humoral immune activity in COVID19‐infected kidney transplant recipients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evidence of potent humoral immune activity in COVID19‐infected kidney transplant recipients
Creator	Rahman, Adeeb Benedetti, Claudia Bin, Sofia Cravedi, Paolo Florman, Sander Gallon, Lorenzo Hartzell, Susan Haverly, Meredith Heeger, Peter Leech, John Menon, Madhav Riella, Leonardo Zaza, Gianluigi
source	Medline; PMC
abstract	Whether kidney transplant recipients are capable of mounting an effective anti‐SARS‐CoV‐2 adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. Herein, we analyzed peripheral blood cell surface and intracellular cytokine phenotyping by flow cytometry along with serum antibody testing in 18 kidney transplant recipients with active COVID‐19 infection and 36 matched, transplanted controls without COVID‐19. We observed significantly fewer total lymphocytes, fewer circulating memory CD4(+) and CD8(+) T cells in the COVID‐19 subjects. We also showed fewer anergic and senescent CD8(+) T cells in COVID‐19 individuals, but no differences in exhausted CD8(+) T cells, nor in any of these CD4(+) T cell subsets between groups. We also observed greater frequencies of activated B cells in the COVID‐19 patients. Sixteen of 18 COVID‐19 subjects tested for anti‐SARS‐CoV‐2 serum antibodies showed positive IgM or IgG titers. Additional analyses showed no significant correlation s among immune phenotypes and degrees of COVID‐19 disease severity. Our findings indicate that immunosuppressed kidney transplant recipients admitted to the hospital with acute COVID‐19 infection can mount SARS‐CoV‐2‐reactive adaptive immune responses. The findings raise the possibility that empiric reductions in immunosuppressive therapy for all kidney transplant recipients with active COVID‐19 may not be required.
has issue date	2020-08-12(xsd:dateTime)
bibo:doi	10.1111/ajt.16261
bibo:pmid	32786152
has license	no-cc
sha1sum (hex)	30b7a6e70bf11009ef15cf8d14c4392e3ba2ff09
schema:url	https://doi.org/10.1111/ajt.16261
resource representing a document's title	Evidence of potent humoral immune activity in COVID19‐infected kidney transplant recipients
has PubMed Central identifier	PMC7436882
has PubMed identifier	32786152
schema:publication	Am J Transplant
resource representing a document's body	covid:30b7a6e70bf11009ef15cf8d14c4392e3ba2ff09#body_text
is schema:about of	named entity 'Evidence' named entity 'kidney transplant' named entity 'peripheral blood' named entity 'CD19' named entity 'transplant recipients' named entity 'blood collection' named entity 'global pandemic' named entity 'IgD' named entity 'University Hospital' named entity 'CD8 +' named entity 'kidney transplant' named entity 'biopsy' named entity 'Coronavirus disease 2019' named entity 'clinical symptoms' named entity 'PD1' named entity 'follow-up' named entity 'CD138' named entity 'COVID' named entity 'plasmablasts' named entity 'CD4 +' named entity 'memory T cells' named entity 'phenotypes' named entity 'KLRG1' named entity 'CD8 +' named entity 'nasopharyngeal swab' named entity 'Treg' named entity 'IgG' named entity 'IgG' named entity 'SARS-CoV-2' named entity 'Kidney Donor' named entity 'transplant recipients' named entity 'Treg' named entity 'infection' named entity 'CD127' named entity 'blood plasma' named entity 'peripheral blood' named entity 'CCR6' named entity 'CD19' named entity 'peripheral blood' named entity 'diabetes' named entity 'Mount Sinai Hospital' named entity 'infection' named entity 'general population' named entity 'CD4 +' named entity 'IgM' named entity 'COVID-19' named entity 'lymphocyte' named entity 'San Diego' named entity 'COVID-19' named entity 'ferritin' named entity 'infection' named entity 'RT-PCR' named entity 'COVID' named entity 'COVID' named entity 'COVID-19' named entity 'COVID' named entity 'class switch recombination' named entity 'senescent' named entity 'COVID' named entity 'COVID' named entity 'lymphocyte' named entity 'bone marrow' named entity 'transplant recipients' named entity 'Remicade' named entity 'SARS-CoV-2' named entity 'CD8 +' named entity 'CD19' named entity 'immunosuppression' named entity 'LAG3'

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