About: Aspergillus PCR in Bronchoalveolar Lavage Fluid for the Diagnosis and Prognosis of Aspergillosis in Patients With Hematological and Non-hematological Conditions

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About: Aspergillus PCR in Bronchoalveolar Lavage Fluid for the Diagnosis and Prognosis of Aspergillosis in Patients With Hematological and Non-hematological Conditions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Aspergillus PCR in Bronchoalveolar Lavage Fluid for the Diagnosis and Prognosis of Aspergillosis in Patients With Hematological and Non-hematological Conditions
Creator	Brossas, Jean-Yves Fekkar, Arnaud Gay, Frédérick Imbert, Sébastien Meyer, Isabelle Palous, Martine Touafek, Feriel Trosini-Desert, Valéry Uzunov, Madalina Lamoth, Frederic Cruciani, Mario Hoenigl, Martin Lewis, Scaligera, Italy Ulss, Azienda
Source	PMC
abstract	Objectives: We evaluated the usefulness of an Aspergillus fumigatus quantitative PCR assay performed in bronchoalveolar lavage fluid (BAL) for the diagnosis and prognosis of both invasive and non-invasive aspergillosis. Methods: This 4-year retrospective study involved 613 at-risk patients who had either hematological disorders or other immunosuppressive conditions, notably solid organ transplants. Thirty-five patients had proven/probable aspergillosis and thirteen had chronic non-invasive aspergillosis. We compared PCR, galactomannan index and mycological analysis of BAL. Results: For invasive aspergillosis (IA), PCR performed in BAL yielded 88.6% sensitivity and 95.5% specificity. Comparatively, galactomannan index and mycological examination yielded only 56.3 and 63.6% sensitivity and 97.6 and 94.5% specificity, respectively. Considering the 13 chronic aspergillosis cases, PCR, galactomannan index and mycological examination yielded 76.9, 15.4, and 84.6% sensitivity and 92.2, 94.9, and 93% specificity, respectively. Fungal load in BAL evaluated by PCR was able to discriminate between aspergillosis and contamination, but not between invasive and non-invasive forms. Finally, fungal load was predictive of 90-day mortality, with 23.1% mortality for patients with less than 500 copies/mL versus 68.4% for patients above that cut-off (p < 0.05). Conclusion: Our results indicate that Aspergillus PCR in BAL is of particular interest for both the diagnosis and the prognosis of IA. It is likewise an interesting tool for the diagnosis of non-invasive forms.
has issue date	2018-08-14(xsd:dateTime)
bibo:doi	10.3389/fmicb.2018.01877
bibo:pmid	30154779
has license	cc-by
sha1sum (hex)	30e8d03a5cf6907154b5a3d7c7b23cdc96cf1952
schema:url	https://doi.org/10.3389/fmicb.2018.01877
resource representing a document's title	Aspergillus PCR in Bronchoalveolar Lavage Fluid for the Diagnosis and Prognosis of Aspergillosis in Patients With Hematological and Non-hematological Conditions
has PubMed Central identifier	PMC6102318
has PubMed identifier	30154779
schema:publication	Front Microbiol
resource representing a document's body	covid:30e8d03a5cf6907154b5a3d7c7b23cdc96cf1952#body_text
is schema:about of	named entity 'Patients' named entity 'Diagnosis' named entity 'PCR' named entity 'PATIENTS' named entity 'NON-INVASIVE' named entity 'INVASIVE' named entity 'PERFORMED' named entity 'DIAGNOSIS' named entity 'QUANTITATIVE PCR' named entity 'ASPERGILLUS FUMIGATUS' named entity 'INVASIVE ASPERGILLOSIS' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'OBJECTIVES' named entity 'EVALUATED' covid:arg/30e8d03a5cf6907154b5a3d7c7b23cdc96cf1952 named entity 'PCR ASSAY' named entity 'DIAGNOSIS' named entity 'HEMATOLOGICAL' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'ASPERGILLUS' named entity 'PROGNOSIS' named entity 'CONDITIONS' named entity 'PROGNOSIS' named entity 'ASPERGILLOSIS' named entity 'USEFULNESS' named entity 'NON-' named entity 'invasive' named entity 'bronchoalveolar lavage fluid' named entity 'With' named entity 'quantitative PCR' named entity 'prognosis' named entity 'aspergillosis' named entity 'PCR' named entity 'Infectious Diseases' named entity 'NPV' named entity 'aspergillosis' named entity 'A. fumigatus' named entity 'real-time polymerase chain reaction' named entity 'neutropenic' named entity 'PCR' named entity 'real-time PCR' named entity 'prognosis' named entity 'DNA extraction' named entity 'PCR' named entity 'PCR technique' named entity 'yeast' named entity 'gold standard' named entity 'Aspergillus' named entity 'blood samples' named entity 'aspergilloma' named entity 'EORTC' named entity 'neutropenic' named entity '95% CI' named entity 'data analysis' named entity 'caspofungin' named entity 'false-negative' named entity 'PCR' named entity 'PCR' named entity 'clinician' named entity 'Treatment of Cancer' named entity 'thoracic' named entity 'solid organ transplant' named entity 'PCR' named entity 't-test' named entity '95% CI' named entity 'aspergillosis' named entity 't-test'

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