About: Experimental screening studies on rabies virus transmission and oral rabies vaccination of the Greater Kudu (Tragelaphus strepsiceros)

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About: Experimental screening studies on rabies virus transmission and oral rabies vaccination of the Greater Kudu (Tragelaphus strepsiceros) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Experimental screening studies on rabies virus transmission and oral rabies vaccination of the Greater Kudu (Tragelaphus strepsiceros)
Creator	Müller, Thomas Höper, Dirk Finke, Stefan Bruwer, Floris Clausen, Peter Hassel, Rainer Hundt, Boris Jago, Mark Kabajani, Juliet Khaiseb, Siegfried Lindeque, Pauline Moore, Susan Pfaff, Florian Vos, Ad Freuling, Conrad Van Der Westhuizen, Jolandie
Source	Medline; PMC
abstract	Rabies in the Greater Kudu (Tragelaphus strepsiceros) in Namibia is unique and found in such magnitude as has not been reported elsewhere in southern Africa. Reasons as to why Kudus appear to be exceptionally susceptible to rabies still remain speculative at best. Because the current severe rabies endemic in Kudus continues to have an enormous negative impact on the Namibian agricultural sector, we set out to question existing dogmas regarding the epidemiology of the disease in a unique experimental setting. In addition, we explored effective measures to protect these antelopes. Although we were able to confirm high susceptibly of kudus for rabies and sporadic horizontal rabies virus transmission to contact animals, we contend that these observations cannot plausibly explain the rapid spread of the disease in Kudus over large territories. Since parenteral vaccination of free-roaming Kudus is virtually impossible, oral rabies vaccination using modified life virus vaccines with a high safety profile would be the ultimate solution to the problem. In a proof-of-concept study using a 3rd generation oral rabies virus vaccine construct (SPBN GASGAS) we found evidence that Kudus can be vaccinated by the oral route and protected against a subsequent rabies infection. In a second phase, more targeted studies need to be initiated by focusing on optimizing oral vaccine uptake and delivery.
has issue date	2018-11-09(xsd:dateTime)
bibo:doi	10.1038/s41598-018-34985-5
bibo:pmid	30413745
has license	cc-by
sha1sum (hex)	31d093e41e871ccc4472ec4bcfccb4a94a46653e
schema:url	https://doi.org/10.1038/s41598-018-34985-5
resource representing a document's title	Experimental screening studies on rabies virus transmission and oral rabies vaccination of the Greater Kudu (Tragelaphus strepsiceros)
has PubMed Central identifier	PMC6226427
has PubMed identifier	30413745
schema:publication	Sci Rep
resource representing a document's body	covid:31d093e41e871ccc4472ec4bcfccb4a94a46653e#body_text
is schema:about of	named entity 'rabies' named entity 'confirm' named entity 'contact' named entity 'vaccination' named entity 'safety' named entity 'horizontal' named entity 'strepsiceros' named entity 'EXPERIMENTAL' named entity 'STUDIES' named entity 'EFFECTIVE' named entity 'DELIVERY' named entity 'PROBLEM' named entity 'PARENTERAL' named entity 'SEVERE' named entity 'FOCUSING' named entity 'DISEASE' named entity 'TO CONTACT' named entity 'SET' named entity 'MAGNITUDE' named entity 'VACCINATION' named entity 'SPORADIC' named entity 'PROFILE' named entity 'SOUTHERN AFRICA' named entity 'STUDIES' named entity '3RD' named entity 'GENERATION' named entity 'HAVE' named entity 'SAFETY' named entity 'NEGATIVE' named entity 'HIGH' named entity 'PROOF' named entity 'CONFIRM' named entity 'ORAL RABIES VACCINATION' named entity 'THESE' named entity 'ORAL' named entity 'TRANSMISSION' named entity 'STUDY' named entity 'USING' named entity 'BEST' named entity 'REPORTED' named entity 'RAPID' named entity 'GREATER KUDU' named entity 'RABIES' named entity 'NEED' named entity 'ADDITION' named entity 'EVIDENCE' named entity 'TARGETED' named entity 'SECOND PHASE' named entity 'IMPOSSIBLE' named entity 'NAMIBIA' named entity 'ANTELOPES' named entity 'WHY' named entity 'OF FREE' named entity 'MODIFIED' named entity 'RABIES VIRUS VACCINE' named entity 'CONCEPT' named entity 'SOLUTION' named entity 'CURRENT' named entity 'CONSTRUCT' named entity 'TRANSMISSION' named entity 'ORAL VACCINE' named entity 'RABIES VIRUS' named entity 'SCREENING' named entity 'LIFE' named entity 'OBSERVATIONS' named entity 'ORAL ROUTE'

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