About: IFN-γ establishes interferon-stimulated gene-mediated antiviral state against Newcastle disease virus in chicken fibroblasts

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About: IFN-γ establishes interferon-stimulated gene-mediated antiviral state against Newcastle disease virus in chicken fibroblasts Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	IFN-γ establishes interferon-stimulated gene-mediated antiviral state against Newcastle disease virus in chicken fibroblasts
Creator	Yang, Xin Liu, Xingjian Zhang, Zhifang Li, Yinü Arslan, Mehboob Du, Mengtan Song, Haozhi
source	PMC
abstract	Newcastle disease virus (NDV) causes severe economic losses through severe morbidity and mortality and poses a significant threat to the global poultry industry. Significant efforts have been made to develop novel vaccines and therapeutics; however, the interaction of NDV with the host is not yet fully understood. Interferons (IFNs), an integral component of innate immune signaling, act as the first line of defense against invading viruses. Compared with the mammalian repertoire of IFNs, limited information is available on the antiviral potential of IFNs in chickens. Here, we expressed chicken IFN-γ (chIFN-γ) using a baculovirus expression vector system, characterized its antiviral potential against NDV, and determined its antiviral potential. Priming of chicken embryo fibroblasts with chIFN-γ elicited an antiviral environment in primary cells, which was mainly due to interferon-stimulated genes (ISGs). A genome-wide transcriptomics approach was used to elucidate the possible signaling pathways associated with IFN-γ-induced immune responses. RNA-sequencing (RNA-seq) data revealed significant induction of ISG-associated pathways, activated temporal expression of ISGs, antiviral mediators, and transcriptional regulators in a cascade of antiviral responses. Collectively, we found that IFN-γ significantly elicited an antiviral response against NDV infection. These data provide a foundation for chIFN-γ-mediated antiviral responses and underpin functional annotation of these important chIFN-γ-induced antiviral influencers.
has issue date	2020-02-11(xsd:dateTime)
bibo:doi	10.1093/abbs/gmz158
bibo:pmid	32047904
has license	no-cc
sha1sum (hex)	31ddc479740311f05ff903e54a6c650c903302e8
schema:url	https://doi.org/10.1093/abbs/gmz158
resource representing a document's title	IFN-γ establishes interferon-stimulated gene-mediated antiviral state against Newcastle disease virus in chicken fibroblasts
has PubMed Central identifier	PMC7109688
has PubMed identifier	32047904
schema:publication	Acta Biochim Biophys Sin (Shanghai)
resource representing a document's body	covid:31ddc479740311f05ff903e54a6c650c903302e8#body_text
is schema:about of	named entity 'integral' named entity 'host' named entity 'chickens' named entity 'fibroblasts' named entity 'BACULOVIRUS' named entity 'THERAPEUTICS' named entity 'ANTIVIRAL' named entity 'INDUCED' named entity 'REPERTOIRE' named entity 'PRIMING' named entity 'EXPRESSION' named entity 'USING' named entity 'ECONOMIC' named entity 'IMMUNE RESPONSES' named entity 'ACTIVATED' named entity 'REVEALED' named entity 'LINE' named entity 'CASCADE' named entity 'TRANSCRIPTOMICS' named entity 'EMBRYO' named entity 'CHICKEN' named entity 'WIDE' named entity 'REGULATORS' named entity 'SEQ' named entity 'VIRUSES' named entity 'IFN' covid:arg/31ddc479740311f05ff903e54a6c650c903302e8 named entity 'GENE' named entity 'LIMITED' named entity 'SYSTEM' named entity 'RESPONSES' named entity 'FOUND' named entity 'IMMUNE' named entity 'POTENTIAL' named entity 'TRANSCRIPTIONAL' named entity 'EXPRESSION VECTOR' named entity 'POSSIBLE' named entity 'ELICITED' named entity 'IFN' named entity 'FIBROBLASTS' named entity 'STATE' named entity 'INTERFERON' named entity 'ANTIVIRAL' named entity 'CHARACTERIZED' named entity 'INDUCTION' named entity 'SIGNIFICANT' named entity 'DEFENSE' named entity 'SEVERE' named entity 'SIGNALING' named entity 'HAVE' named entity 'INFECTION' named entity 'INTERFERON' named entity 'COMPONENT' named entity 'MAMMALIAN' named entity 'STIMULATED' named entity 'CAUSES' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'UNDERSTOOD' named entity 'USED' named entity 'APPROACH' named entity 'POULTRY INDUSTRY' named entity 'ISG' named entity 'CHICKENS' named entity 'HOST' named entity 'DUE TO' named entity 'MEDIATED' named entity 'CHICKEN' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'STIMULATED' named entity 'ITS' named entity 'MEDIATED' named entity 'PATHWAYS' named entity 'NOVEL' named entity 'THREAT' named entity 'MEDIATORS'

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