About: Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic

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About: Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic
Creator	Kennedy, Melissa Rajeev, Sreekumari Lleonart, Ricardo Restrepo, Carlos Caballero, Zuleima Llanes, Alejandro
Source	Medline; PMC
abstract	In the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin and mode of transmission of coronaviruses in the aftermath of the 2002–2003 severe acute respiratory syndrome (SARS) and 2012 Middle East respiratory syndrome (MERS) outbreaks. Furthermore, genome sequencing and bioinformatic analysis have had an unprecedented relevance in the battle against the 2019–2020 coronavirus disease 2019 (COVID-19) pandemic, the newest and most devastating outbreak caused by a coronavirus in the history of mankind. Here, we review how genomic information has been used to tackle outbreaks caused by emerging, highly pathogenic, betacoronavirus strains, emphasizing on SARS-CoV, MERS-CoV and SARS-CoV-2. We focus on shared genomic features of the betacoronaviruses and the application of genomic information to phylogenetic analysis, molecular epidemiology and the design of diagnostic systems, potential drugs and vaccine candidates.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.3390/ijms21124546
bibo:pmid	32604724
has license	cc-by
sha1sum (hex)	31e062940335563d9d1c7a6d8d4c796746d0f0a4
schema:url	https://doi.org/10.3390/ijms21124546
resource representing a document's title	Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic
has PubMed Central identifier	PMC7352669
has PubMed identifier	32604724
schema:publication	Int J Mol Sci
resource representing a document's body	covid:31e062940335563d9d1c7a6d8d4c796746d0f0a4#body_text
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