About: Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations

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About: Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations
Creator	Sørensen, Poul Bergman, Ingrid-Maria Dalgaard, Tina Juul-Madsen, Helle Kjaerup, Rikke Norup, Liselotte
Source	Elsevier; Medline; PMC
abstract	Abstract Mannose-binding lectin (MBL) plays a major role in the immune response as a soluble pattern-recognition receptor. MBL deficiency and susceptibility to different types of infections have been subject to extensive studies over the last decades. In humans and chickens, several studies have shown that MBL participates in the protection of hosts against virus infections. Infectious bronchitis (IB) is a highly contagious disease of economic importance in the poultry industry caused by the coronavirus infectious bronchitis virus (IBV). MBL has earlier been described to play a potential role in the pathogenesis of IBV infection and the production of IBV-specific antibodies, which may be exploited in optimising IBV vaccine strategies. The present study shows that MBL has the capability to bind to IBV in vitro. Chickens from two inbred lines (L10H and L10L) selected for high or low MBL serum concentrations, respectively, were vaccinated against IBV with or without the addition of the MBL ligands mannan, chitosan and fructooligosaccharide (FOS). The addition of MBL ligands to the IBV vaccine, especially FOS, enhanced the production of IBV-specific IgG antibody production in L10H chickens, but not L10L chickens after the second vaccination. The addition of FOS to the vaccine also increased the number of circulating CD4+ cells in L10H chickens compared to L10L chickens. The L10H chickens as well as the L10L chickens also showed an increased number of CD4−CD8α−γδ T-cells when an MBL ligand was added to the vaccine, most pronouncedly after the first vaccination. As MBL ligands co-administered with IBV vaccine induced differences between the two chicken lines, these results indirectly suggest that MBL is involved in the immune response to IBV vaccination. Furthermore, the higher antibody response in L10H chickens receiving vaccine and FOS makes FOS a potential adjuvant candidate in an IBV vaccine.
has issue date	2014-04-30(xsd:dateTime)
bibo:doi	10.1016/j.imbio.2013.10.013
bibo:pmid	24305086
has license	els-covid
sha1sum (hex)	329b4aa757557f56f89d796a0034cd3fe4bf983c
schema:url	https://doi.org/10.1016/j.imbio.2013.10.013
resource representing a document's title	Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations
has PubMed Central identifier	PMC7114666
has PubMed identifier	24305086
schema:publication	Immunobiology
resource representing a document's body	covid:329b4aa757557f56f89d796a0034cd3fe4bf983c#body_text
is schema:about of	named entity 'CONCENTRATIONS' named entity 'studies' named entity 'IBV' named entity 'vaccine' named entity 'play' named entity 'ligands' named entity 'antibody' named entity 'pathogenesis' named entity 'MBL' named entity 'CD4+ cells' named entity 'MBL' named entity 'response' named entity 'vaccine' named entity 'MBL' named entity 'participates' named entity 'immune response' named entity 'CHICKENS' named entity 'HIGH' named entity 'BRONCHITIS VACCINE' named entity 'LIGANDS' named entity 'RESPONSE TO' named entity 'MANNOSE-BINDING LECTIN' named entity 'PATHOGENESIS' named entity 'CHITOSAN' named entity 'SELECTED' named entity 'SUSCEPTIBILITY' named entity 'COMPARED' named entity 'STUDY' named entity 'A MAJOR' named entity 'ADDED' named entity 'IN VITRO' named entity 'IGG ANTIBODY' named entity 'PROTECTION' named entity 'STUDIES' named entity 'FOS' named entity 'ADMINISTERED' named entity 'SERUM' named entity 'PRODUCTION' named entity 'CANDIDATE' named entity 'INCREASED NUMBER OF' named entity 'DESCRIBED' named entity 'RECEIVING' named entity 'ADJUVANT' named entity 'RESPONSE TO' named entity 'CORONAVIRUS' named entity 'HAVE' named entity 'MANNOSE-BINDING LECTIN' named entity 'SERUM' named entity 'INFECTIOUS BRONCHITIS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'IS A' named entity 'LOW' named entity 'INBRED' named entity 'IMMUNE RESPONSE' named entity 'LOW' named entity 'LINES' named entity 'MBL' named entity 'PATTERN' named entity 'INCREASED' named entity 'INFECTIONS' named entity 'PRESENT' named entity 'VACCINATION' named entity 'ENHANCED' named entity 'THESE' named entity 'POULTRY INDUSTRY' named entity 'INFECTION' named entity 'ANTIBODY RESPONSE' named entity 'TO BIND TO' named entity 'LIGANDS' named entity 'TYPES OF INFECTIONS' named entity 'BUT' named entity 'HIGHLY CONTAGIOUS DISEASE' named entity 'MAY BE' named entity 'SOLUBLE' named entity 'CHICKENS' named entity 'IMMUNE RESPONSE'

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