About: Proteomics computational analyses suggest that baculovirus GP64 superfamily proteins are class III penetrenes

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About: Proteomics computational analyses suggest that baculovirus GP64 superfamily proteins are class III penetrenes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proteomics computational analyses suggest that baculovirus GP64 superfamily proteins are class III penetrenes
Creator	Garry, Robert Garry, Courtney
topic	covid:330c656592e9917ebc7c9c1703ddaa3d9df809bf#this
Source	Medline; PMC
abstract	BACKGROUND: Members of the Baculoviridae encode two types of proteins that mediate virus:cell membrane fusion and penetration into the host cell. Alignments of primary amino acid sequences indicate that baculovirus fusion proteins of group I nucleopolyhedroviruses (NPV) form the GP64 superfamily. The structure of these viral penetrenes has not been determined. The GP64 superfamily includes the glycoprotein (GP) encoded by members of the Thogotovirus genus of the Orthomyxoviridae. The entry proteins of other baculoviruses, group II NPV and granuloviruses, are class I penetrenes. RESULTS: Class III penetrenes encoded by members of the Rhabdoviridae and Herpesviridae have an internal fusion domain comprised of beta sheets, other beta sheet domains, an extended alpha helical domain, a membrane proximal stem domain and a carboxyl terminal anchor. Similar sequences and structural/functional motifs that characterize class III penetrenes are located collinearly in GP64 of group I baculoviruses and related glycoproteins encoded by thogotoviruses. Structural models based on a prototypic class III penetrene, vesicular stomatitis virus glycoprotein (VSV G), were established for Thogoto virus (THOV) GP and Autographa california multiple NPV (AcMNPV) GP64 demonstrating feasible cysteine linkages. Glycosylation sites in THOV GP and AcMNPV GP64 appear in similar model locations to the two glycosylation sites of VSV G. CONCLUSION: These results suggest that proteins in the GP64 superfamily are class III penetrenes.
has issue date	2008-02-18(xsd:dateTime)
bibo:doi	10.1186/1743-422x-5-28
bibo:pmid	18282283
has license	cc-by
sha1sum (hex)	330c656592e9917ebc7c9c1703ddaa3d9df809bf
schema:url	https://doi.org/10.1186/1743-422x-5-28
resource representing a document's title	Proteomics computational analyses suggest that baculovirus GP64 superfamily proteins are class III penetrenes
has PubMed Central identifier	PMC2288602
has PubMed identifier	18282283
schema:publication	Virol J
resource representing a document's body	covid:330c656592e9917ebc7c9c1703ddaa3d9df809bf#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/330c656592e9917ebc7c9c1703ddaa3d9df809bf
is schema:about of	named entity 'SUGGEST' named entity 'Members' named entity 'cell membrane' named entity 'glycoprotein' named entity 'fusion proteins' named entity 'NPV' named entity 'class III' named entity 'VIROLOGY' named entity 'HOST CELL' named entity 'VIRAL' named entity 'BACULOVIRIDAE' named entity 'PENETRATION' named entity 'GROUP I' named entity 'VIRUS' named entity 'NUCLEOPOLYHEDROVIRUSES' named entity 'INCLUDES' named entity 'CLASS I' named entity 'MEMBERS' named entity 'BACULOVIRUSES' named entity 'DETERMINED' named entity 'PROTEINS' named entity 'SUPERFAMILY' named entity 'GROUP II' named entity 'PROTEOMICS' named entity 'SUPERFAMILY' named entity 'THESE' named entity 'STRUCTURE' named entity 'FUSION' named entity 'MEDIATE' named entity 'PROTEINS' named entity 'TYPES' named entity 'CLASS III' named entity 'COMPUTATIONAL' named entity 'BACULOVIRUS' named entity 'JOURNAL ' named entity 'GLYCOPROTEIN' named entity 'BACULOVIRUS' named entity 'AMINO ACID SEQUENCES' named entity 'ENCODE' named entity 'THOGOTOVIRUS' named entity 'BACKGROUND' named entity 'PRIMARY' named entity 'ORTHOMYXOVIRIDAE' named entity 'FORM' named entity 'NPV' named entity 'ENTRY' named entity 'MEMBRANE FUSION' named entity 'GENUS' named entity 'ENCODED' covid:arg/330c656592e9917ebc7c9c1703ddaa3d9df809bf named entity 'penetration' named entity 'group I' named entity 'virus' named entity 'encoded' named entity 'acid' named entity 'proteins' named entity 'Thogotovirus' named entity 'sequences' named entity 'baculovirus' named entity 'genus' named entity 'Baculoviridae' named entity 'superfamily' named entity 'Thogotovirus' named entity 'structure' named entity 'fusion proteins' named entity 'genus' named entity 'sequence similarity' named entity 'glycosylation sites' named entity 'glycoprotein' named entity 'multimers' named entity 'transmembrane helices' named entity 'torovirus' named entity 'VSV' named entity 'tertiary folding' named entity 'Roche' named entity 'influenza' named entity 'THOV' named entity 'class II'

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