About: Post‐translational regulation of antiviral innate signaling

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Post‐translational regulation of antiviral innate signaling
Creator	Wang, Lin Ge, Baoxue He, Chenxi Zhou, Yilong
Source	Medline; PMC
abstract	The innate immune system initiates immune responses by pattern‐recognition receptors (PRR). Virus‐derived nucleic acids are sensed by the retinoic acid‐inducible gene I (RIG‐I)‐like receptor (RLR) family and the toll‐like receptor (TLR) family as well as the DNA sensor cyclic GMP‐AMP (cGAMP) synthase (cGAS). These receptors activate IRF3/7 and NF‐κB signaling pathways to induce the expression of type I interferons (IFNs) and other cytokines firing antiviral responses within the cell. However, to achieve a favorable outcome for the host, a balanced production of IFNs and activation of antiviral responses is required. Post‐translational modifications (PTMs), such as the covalent linkage of functional groups to amino acid chains, are crucial for this immune homeostasis in antiviral responses. Canonical PTMs including phosphorylation and ubiquitination have been extensively studied and other PTMs such as methylation, acetylation, SUMOylation, ADP‐ribosylation and glutamylation are being increasingly implicated in antiviral innate immunity. Here we summarize our recent understanding of the most important PTMs regulating the antiviral innate immune response, and their role in virus‐related immune pathogenesis.
has issue date	2017-08-14(xsd:dateTime)
bibo:doi	10.1002/eji.201746959
bibo:pmid	28744851
has license	no-cc
sha1sum (hex)	33538ad82c9f74e08f76364611e35e76f2d562e3
schema:url	https://doi.org/10.1002/eji.201746959
resource representing a document's title	Post‐translational regulation of antiviral innate signaling
has PubMed Central identifier	PMC7163624
has PubMed identifier	28744851
schema:publication	Eur J Immunol
resource representing a document's body	covid:33538ad82c9f74e08f76364611e35e76f2d562e3#body_text
is schema:about of	named entity 'THEIR' named entity 'INNATE IMMUNITY' named entity 'innate immune response' named entity 'summarize' named entity 'antiviral' named entity 'innate immune response' named entity 'antiviral' named entity 'SUMOylation' named entity 'virus' named entity 'signaling protein' named entity 'type I IFNs' named entity 'CYLD' named entity 'histone deacetylase' named entity 'ubiquitin' named entity 'transcription factor' named entity 'TRAF6' named entity 'acetylated' named entity 'immunostimulatory' named entity 'RNF135' named entity 'NF-κB' named entity 'antiviral' named entity 'ubiquitinated' named entity 'p65' named entity 'RIG-I' named entity 'protease' named entity 'inducible gene' named entity 'microbes' named entity 'MAVS' named entity 'TBK1' named entity 'induce the expression' named entity 'RNF26' named entity 'methylation' named entity 'dephosphorylation' named entity 'PKCα' named entity 'SUMOylation' named entity 'PTEN' named entity 'SUMOylation' named entity 'p65' named entity 'kinase' named entity 'gene expression' named entity 'phosphorylating' named entity 'antiviral' named entity 'proteolytic degradation' named entity 'phosphorylated' named entity 'cytoplasmic domain' named entity 'acetylation' named entity 'cGAS' named entity 'RIG-I' named entity 'murine' named entity 'IRF3' named entity 'transcription' named entity 'TRAF6' named entity 'UCHL1' named entity 'RIG-I' named entity 'toll-like receptor' named entity 'protein' named entity 'Ubiquitin' named entity 'IRF3' named entity 'cGAS' named entity 'RNA virus infections' named entity 'HOIP' named entity 'ubiquitination' named entity 'E3 ligase' named entity 'Myd88' named entity 'systemic lupus erythematosus' named entity 'protease' named entity 'protein kinase' named entity 'ubiquitination' named entity 'RIG-I' named entity 'TRAF6' named entity 'mitochondrial' named entity 'IRF3' named entity 'PP1α' named entity 'MyD88' named entity 'OTUB2' named entity 'signaling proteins' named entity 'innate immunity' named entity 'PTM'

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