About: Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins

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About: Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins
Creator	Chutiwitoonchai, Nopporn Hashimoto, Michihiro Hiyoshi, Masateru Hiyoshi-Yoshidomi, Yuka Suzu, Shinya Tokunaga, Kenzo
Source	Elsevier; Medline; PMC
abstract	IFN-inducible IFITM proteins (IFITM1, 2, and 3) inhibit the replication of various viruses including HIV-1 through poorly understood mechanisms. Here, we further analyzed characteristics of these newly identified HIV-1 restriction factors. Firstly, in contrast to other anti-HIV-1 proteins, such as tetherin and APOBEC3G, IFITMs were resistant to a down-regulation of surface expression or degradation by HIV-1 proteins. Secondly, the enforced expression of IFITMs reduced the production of HIV-1 viruses from cells transfected with proviral plasmids containing whole viral sequences. Although their inhibitory activities were modest when compared to that of tetherin, IFITMs, but not tetherin, directly reduced the expression of HIV-1 proteins including Gag, Vif and Nef. Of importance, however, IFITMs had no inhibitory effect when these viral proteins were expressed by codon-optimized cDNAs that bypassed the viral-specific expression machinery. Indeed, our results supported the idea that IFITMs interfere with viral protein expression mediated by double-stranded viral RNAs, such as RRE and TAR. Finally, the S-palmitoylation of IFITMs, which is crucial for their anti-influenza virus activity, was not required for their anti-HIV-1 activity, indicating that IFITMs restrict these viruses at different steps. These characteristics lead to a better understanding of the mechanism by which IFITMs restrict HIV-1 and other viruses.
has issue date	2013-01-30(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2012.12.003
bibo:pmid	23376165
has license	no-cc
sha1sum (hex)	3364596826c6341e4d0d914c3a175ef9c23dbf6f
schema:url	https://doi.org/10.1016/j.micinf.2012.12.003
resource representing a document's title	Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins
has PubMed Central identifier	PMC7110712
has PubMed identifier	23376165
schema:publication	Microbes Infect
resource representing a document's body	covid:3364596826c6341e4d0d914c3a175ef9c23dbf6f#body_text
is schema:about of	named entity 'replication' named entity 'bypassed' named entity 'These' named entity 'restriction' named entity 'proteins' named entity 'SPECIFIC' named entity 'ACTIVITIES' named entity 'EXPRESSION' named entity 'VARIOUS' named entity 'FIRSTLY' named entity 'HIV-1' named entity 'INTERFERE' named entity 'INHIBITORY EFFECT' named entity 'RESTRICTION' named entity 'REDUCED' named entity 'IFN' named entity 'PROTEINS' named entity 'CONTRAST' named entity 'IDENTIFIED' named entity 'STEPS' named entity 'MEDIATED' named entity 'RESTRICT' named entity 'CELLS' named entity 'SEQUENCES' named entity 'ANTI-HIV-1 ACTIVITY' named entity 'OUR' covid:arg/3364596826c6341e4d0d914c3a175ef9c23dbf6f named entity 'REPLICATION' named entity 'INFLUENZA VIRUS' named entity 'MECHANISMS' named entity 'SURFACE' named entity 'SUPPORTED' named entity 'INDUCIBLE' named entity 'PROTEINS' named entity 'FAMILY' named entity 'ANTI-HIV' named entity 'IDENTIFIED' named entity 'NEWLY' named entity 'IFN' named entity 'HIV-1' named entity 'TETHERIN' named entity 'PROTEIN EXPRESSION' named entity 'S-PALMITOYLATION' named entity 'VIRAL PROTEINS' named entity 'GAG' named entity 'VIRAL PROTEIN' named entity 'RESULTS' named entity 'MACHINERY' named entity 'DEGRADATION' named entity 'UNDERSTOOD' named entity 'CHARACTERISTICS' named entity 'TAR' named entity 'SECONDLY' named entity 'NEWLY' named entity 'UNDERSTANDING' named entity 'RNAS' named entity 'CODON' named entity 'MECHANISM' named entity 'EXPRESSED' named entity 'INDICATING' named entity 'IDEA' named entity 'BUT' named entity 'CONTAINING' named entity 'COMPARED' named entity 'DIRECTLY' named entity 'VIF' named entity 'VIRAL' named entity 'POORLY' named entity 'ANTI-HIV' named entity 'INHIBITORY' named entity 'THESE' named entity 'PRODUCTION' named entity 'ACTIVITY' named entity 'INDUCIBLE' named entity 'RESISTANT TO' named entity 'DOUBLE'

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