About: In vitro evidence of cellular adaptation to ozone toxicity in the rat trachea

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vitro evidence of cellular adaptation to ozone toxicity in the rat trachea
Creator	Dungworth, Donald Nikula, Kristen Plopper, Charles Wilson, Dennis Wilson, K
Source	Elsevier; Medline; PMC
abstract	Abstract Adaptation to prolonged ozone (O3) exposure occurs in the tracheal epithelium of rats and is marked by the presence of ciliated cells with uniform short cilia but is not accompanied by shifts in cell populations, altered characteristics of epithelial secretory cell products, increased cell turnover, or elevated tracheal superoxide dismutase activity. The purpose of this study was to test the hypothesis that adaptation is a result of alterations intrinsic to epithelial cells or to the cells and their matrix, and not due to systemic or neural influences. Rats were preexposed to either filtered air (FA) or 0.96 ppm O3 for 8 hr/night for 60 days, and then their tracheae were removed and exposed to 3 ppm O3 in an explant culture system where behavioral, nasal, exudative, and secretory product influences can be eliminated. After exposure to 3 ppm O3 in vitro, quantitative electron microscopic evaluation demonstrated that the epithelia from the FA preexposure group had significantly more necrotic cells and sloughed cells and fewer ciliated cells than the epithelia from the O3 preexposure group. Thus previous exposure to ozone in vivo induces a change in tracheal epithelium which confers resistance to ozone-induced injury in the explant exposure system.
has issue date	1988-05-31(xsd:dateTime)
bibo:doi	10.1016/0041-008x(88)90042-7
bibo:pmid	3368918
has license	els-covid
sha1sum (hex)	33db094e90e39f558529c568e0d0e373fe21bf7b
schema:url	https://doi.org/10.1016/0041-008x%2888%2990042-7
resource representing a document's title	In vitro evidence of cellular adaptation to ozone toxicity in the rat trachea
has PubMed Central identifier	PMC7130130
has PubMed identifier	3368918
schema:publication	Toxicology and Applied Pharmacology
resource representing a document's body	covid:33db094e90e39f558529c568e0d0e373fe21bf7b#body_text
is schema:about of	named entity 'IN VITRO' named entity 'intrinsic' named entity 'eliminated' named entity 'matrix' named entity 'necrotic' named entity 'Rat' named entity 'Vitro' named entity 'Ozone' named entity 'Trachea' named entity 'EXPOSURE TO OZONE' named entity 'POPULATIONS' named entity 'ADAPTATION' named entity 'CILIA' named entity 'THEIR' named entity 'TO TEST' named entity 'WHERE' named entity 'INCREASED' named entity 'ELECTRON' named entity 'SYSTEM' named entity 'HYPOTHESIS' named entity 'NASAL' named entity 'INJURY' named entity 'ALTERATIONS' named entity 'NECROTIC' named entity 'ALTERED' named entity 'CELL' named entity 'DAYS' named entity 'EPITHELIAL' named entity 'EPITHELIAL CELLS' named entity 'UNIFORM' named entity 'PRESENCE' named entity 'EXPOSURE TO' named entity 'NEURAL' named entity 'ADAPTATION' named entity 'MICROSCOPIC' named entity 'ELEVATED' named entity 'EXPOSURE' named entity 'INTRINSIC' named entity 'AIR' named entity 'TRACHEAL EPITHELIUM' named entity 'PPM' named entity 'RAT TRACHEA' named entity 'EVIDENCE OF' named entity 'OZONE' named entity 'NIKULA' named entity 'DUE TO' named entity 'RESISTANCE TO' named entity 'SLOUGHED' named entity 'PRODUCT' named entity 'SYSTEMIC' named entity 'RESULT' named entity 'EXPLANT' named entity 'BEHAVIORAL' named entity 'SHORT' named entity 'SECRETORY CELL' named entity 'FILTERED' named entity 'RATS' named entity 'CHANGE IN' named entity 'IN VIVO' named entity 'EVALUATION' named entity 'DEMONSTRATED' named entity 'OZONE' named entity 'SHIFTS' named entity 'IN VITRO' named entity 'MATRIX' named entity 'APPI' named entity 'PREVIOUS' named entity 'MARKED' named entity 'EITHER' named entity 'CILIATED CELLS' named entity 'CHARACTERISTICS' named entity 'PRODUCTS' named entity 'REMOVED' named entity 'STUDY' named entity 'TRACHEAL' named entity 'PURPOSE' named entity 'CELLS'

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