About: The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey

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About: The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey
Creator	Navarro, David Giménez, Estela Montoro, Juan Pérez, Ariadna Salavert, Miguel Sanz, Guillermo Lorenzo, Ignacio Carlos Hernández-Boluda, Juan Luis Piñana, José Aitana Balaguer-Roselló, • Carlos, • Guerreiro, • Gómez, Dolores Hernani, • María González-Barberá, Eva María, • Sanz, • Solano, •
Source	Medline; PMC
abstract	The effect of timing of community acquired respiratory virus (CARV) infection after allogeneic hematopoietic stem cell transplant (allo-HCT) is an as yet unsettled issue. We evaluate this issue by including all consecutive allo-HCT recipients with molecularly-documented CARV infection during the first year after transplant. The study cohort was drawn from a prospective longitudinal survey of CARV in allo-HCT recipient having respiratory symptoms conducted from December 2013 to December 2018 at two Spanish transplant centers. Respiratory viruses in upper and/or lower respiratory specimens were tested using multiplex PCR panel assays. The study cohort comprised 233 allo-HCT recipients with 376 CARV infection episodes diagnosed during the first year after allo-HCT. Overall, 60% of CARV episodes occurred within the first 6 months (227 out of 376). Thirty patients (13%) had died at 3 months after CARV detection, of which 25 (83%) were recipients developing CARV within the first 6 months after transplant. Multivariate analysis identified four risk factors for mortality: ATG used as part of conditioning regimen [odds ratio (OR) 2.8, 95% confidence interval (C.I.) 1.21–6.4, p = 0.01], CARV lower respiratory tract disease (OR 3.4, 95% C.I. 1.4–8.4, p = 0.007), CARV infection within the first 6 months of transplant (OR 3.04, 95% C.I. 1.1–8.7, p = 0.03), and absolute lymphocyte count <0.2 × 109/L (OR 2.4, 95% C.I. 1–5.3, p = 0.04). Developing CARV infection within the first 6 months was associated with higher mortality. Our data supports that the timing of CARV development after allo-HCT could be of major interest.
has issue date	2019-09-24(xsd:dateTime)
bibo:doi	10.1038/s41409-019-0698-7
bibo:pmid	31551521
has license	no-cc
sha1sum (hex)	3544b3974fdeb9415092ae530cfc86f81bb30915
schema:url	https://doi.org/10.1038/s41409-019-0698-7
resource representing a document's title	The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey
has PubMed Central identifier	PMC7091566
has PubMed identifier	31551521
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:3544b3974fdeb9415092ae530cfc86f81bb30915#body_text
is schema:about of	named entity 'ATG' named entity 'absolute' named entity 'infection' named entity 'transplantation' named entity 'hematopoietic stem cell' named entity 'RESPIRATORY VIRUS INFECTION' named entity 'MULTIVARIATE ANALYSIS' named entity 'USING' named entity '376' named entity 'CONDITIONING REGIMEN' named entity 'RECIPIENT' named entity '2.4' named entity 'MULTIPLEX PCR' named entity 'COHORT' named entity 'MAJOR' named entity 'RISK FACTORS' named entity 'IDENTIFIED' named entity 'DIAGNOSED' named entity 'LOWER RESPIRATORY TRACT DISEASE' named entity '6.4' named entity 'DIED' named entity 'EFFECT' named entity 'ABSOLUTE LYMPHOCYTE COUNT' named entity '1.4' named entity '2018' named entity 'HEMATOPOIETIC STEM CELL' named entity '0.03' named entity 'RESPIRATORY' covid:arg/3544b3974fdeb9415092ae530cfc86f81bb30915 named entity 'EPIDEMIOLOGICAL SURVEY' named entity 'SPANISH' named entity 'EFFECT' named entity 'LOWER' named entity 'UPPER' named entity 'RESPIRATORY SYMPTOMS' named entity 'TIMING' named entity 'YEAR' named entity 'PROSPECTIVE' named entity 'COMMUNITY ACQUIRED' named entity 'ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION' named entity 'YEAR' named entity 'COULD BE' named entity 'DATA' named entity 'THIRTY' named entity 'HIGHER' named entity 'OCCURRED' named entity '233' named entity 'EPISODES' named entity 'TIMING' named entity '60%' named entity 'TRANSPLANT' named entity 'ALLOGENEIC' named entity 'INFECTION' named entity 'HCT' named entity '1-8' named entity 'INTEREST' named entity 'PROSPECTIVE' named entity 'ISSUE' named entity 'MORTALITY' named entity 'RESPIRATORY VIRUSES' named entity 'COMMUNITY ACQUIRED' named entity '3.4' named entity 'LONGITUDINAL SURVEY' named entity 'DEVELOPING'

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