About: Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children
Creator	Osterhaus, Albert Koopmans, Marion De Hoog, Matthijs Fraaij, Pieter Jeroen, J Moesker, Fleur Van Kampen, Van Rossum, Annemarie
source	Medline; PMC
abstract	BACKGROUND: Respiratory syncytial virus (RSV) and influenza A viruses are known to cause severe acute respiratory tract infections (SARIs) in children. For other viruses like human rhinoviruses (HRVs) this is less well established. Viral or bacterial co-infections are often considered essential for severe manifestations of these virus infections. OBJECTIVE: The study aims at identifying viruses that may cause SARI in children in the absence of viral and bacterial co-infections, at identifying disease characteristics associated with these single virus infections, and at identifying a possible correlation between viral loads and disease severities. STUDY DESIGN: Between April 2007 and March 2012, we identified children (<18 year) with or without a medical history, admitted to our paediatric intensive care unit (PICU) with SARI or to the medium care (MC) with an acute respiratory tract infection (ARTI) (controls). Data were extracted from the clinical and laboratory databases of our tertiary care paediatric hospital. Patient specimens were tested for fifteen respiratory viruses with real-time reverse transcriptase PCR assays and we selected patients with a single virus infection only. Typical bacterial co-infections were considered unlikely to have contributed to the PICU or MC admission based on C-reactive protein-levels or bacteriological test results if performed. RESULTS: We identified 44 patients admitted to PICU with SARI and 40 patients admitted to MC with ARTI. Twelve viruses were associated with SARI, ten of which were also associated with ARTI in the absence of typical bacterial and viral co-infections, with RSV and HRV being the most frequent causes. Viral loads were not different between PICU-SARI patients and MC-ARTI patients. CONCLUSION: Both SARI and ARTI may be caused by single viral pathogens in previously healthy children as well as in children with a medical history. No relationship between viral load and disease severity was identified.
has issue date	2016-03-10(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0150776
bibo:pmid	26964038
has license	cc-by
sha1sum (hex)	3557b5b8c5052a1f7fbb18130ace9427201e0fe4
schema:url	https://doi.org/10.1371/journal.pone.0150776
resource representing a document's title	Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children
has PubMed Central identifier	PMC4786225
has PubMed identifier	26964038
schema:publication	PLoS One
resource representing a document's body	covid:3557b5b8c5052a1f7fbb18130ace9427201e0fe4#body_text
is schema:about of	named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'For' named entity 'Tract' named entity 'Infections' named entity 'VIRUSES' named entity 'CAUSATIVE AGENTS' named entity 'RHINOVIRUSES' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'VIRUSES' named entity 'CHILDREN' named entity 'CO-INFECTIONS' named entity 'BACTERIAL' named entity 'ACUTE' named entity 'INFLUENZA A' named entity 'SEVERE' named entity 'KNOWN' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'SEVERE' named entity 'CHILDREN' named entity 'ACUTE' named entity 'MANIFESTATIONS' named entity 'LIKE' named entity 'CAUSE' named entity 'SOLE' named entity 'VIRUS' named entity 'CONSIDERED' named entity 'VIRAL' named entity 'ESTABLISHED' named entity 'INFECTIONS' named entity 'HUMAN' named entity 'THESE' named entity 'ESSENTIAL' named entity 'Viral' named entity 'respiratory tract infections' named entity 'infections' named entity 'human' named entity 'Causative' named entity 'viruses' named entity 'Respiratory syncytial virus' named entity 'PICU' named entity 'HRV' named entity 'spinal muscular atrophy' named entity 'RSV' named entity 'atypical bacteria' named entity 'cerebrospinal fluid' named entity 'PICU' named entity 'critically ill patients' named entity 'sputum' named entity 'surrogate marker' named entity 'paediatric' named entity 'bacterial infection' named entity 'RSV' named entity 'pre-term birth' named entity 'signs and symptoms' named entity 'CRP' named entity 'co-infection' named entity 'Chlamydophila pneumoniae' named entity '7.5' named entity 'viruses' named entity 'morbidity' named entity 'emergency department' named entity 'non-invasive' named entity 'neonatal intensive care unit' named entity 'PICU' named entity 'influenza A virus' named entity 'high-risk' named entity 'host cell' named entity 'epidemiological data' named entity 'viruses' named entity 'LRTI' named entity 'Informed consent' named entity 'viral pathogens' named entity 'HCoV-229E' named entity 'viral pathogens'

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