About: Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments

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About: Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments
Creator	Naegeli, Hanspeter More, Simon Bambidis, Vasileos Benford, Diane Bennekou, Susanne Bragard, Claude Ciccolallo, Marios Fletcher, Matthias Fletcher, Tony Georgiadis, Andrea Gervelmeyer, Thorhallur Greiner, Evangelia Greiner, Matthias Halldorsson, Halldorsson, Thorhallur Hernandez-Jerez, Antonio Koutsoumanis, Kostas Machera, Kyriaki Nielsen, Josef Ntzani, Evangelia Ntzani, Neil Pearce, Neil Pearce, Marco Schlatter, Dieter Schrenk, Vittorio Silano, Dominique Soren, Saxmose Turck, Maged Vinceti, Laura Vinceti, Marco Younes, Younes, Tony
Source	PMC
abstract	EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an introduction to epidemiological studies and illustrates the typical biases of the different epidemiological study designs. It describes key epidemiological concepts relevant for evidence appraisal. Regarding study reliability, measures of association, exposure assessment, statistical inferences, systematic error and effect modification are explained. Regarding study relevance, the guidance describes the concept of external validity. The principles of appraising epidemiological studies are illustrated, and an overview of Risk of Bias (RoB) tools is given. A decision tree is developed to assist in the selection of the appropriate Risk of Bias tool, depending on study question, population and design. The customisation of the study appraisal process is explained, detailing the use of RoB tools and assessing the risk of bias in the body of evidence. Several examples of appraising experimental and observational studies using a Risk of Bias tool are annexed to the document to illustrate the application of the approach. This document constitutes a draft that will be applied in EFSA's assessments during a 1‐year pilot phase and be revised and complemented as necessary. Before finalisation of the document, a public consultation will be launched.
has issue date	2020-08-18(xsd:dateTime)
bibo:doi	10.2903/j.efsa.2020.6221
has license	cc-by-nd
sha1sum (hex)	355da9c8e517420abc12bac028e2fa6e90879ccc
schema:url	https://doi.org/10.2903/j.efsa.2020.6221
resource representing a document's title	Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments
has PubMed Central identifier	PMC7433401
schema:publication	EFSA J
resource representing a document's body	covid:355da9c8e517420abc12bac028e2fa6e90879ccc#body_text
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