About: Outbreak of macrolide-resistant mycoplasma pneumoniae in a primary school in Beijing, China in 2018

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About: Outbreak of macrolide-resistant mycoplasma pneumoniae in a primary school in Beijing, China in 2018 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Outbreak of macrolide-resistant mycoplasma pneumoniae in a primary school in Beijing, China in 2018
Creator	Wu, Dan Hu, Guang-Yi Jing, Hong-Bo Li, Yin-Dong Wang, Quan-Yi Zhang, Song-Jian Zhang, Wen-Zeng
Source	Medline; PMC
abstract	BACKGROUND: On 7th June, 2018, a primary school in Beijing, China notified Shunyi CDC of an outbreak of acute respiratory disease characterized by fever and cough among students and resulting in nine hospitalization cases during the preceding 2 weeks. We started an investigation to identify the etiologic agent, find additional cases, develop and implement control measures. METHODS: We defined probable cases as students, teachers and other staffs in the school developed fever (T ≥ 37.5 °C) with cough or sore throat; or a diagnosis of pneumonia during May 1–June 31, 2018. Confirmed cases were probable cases with Mycoplasma pneumoniae detected in oropharyngeal (OP) swabs by quantitative real-time polymerase chain reaction (qPCR). We searched case by reviewing school absenteeism records and interviewing students, teachers and staff in this school. Oropharyngeal swabs were collected from symptomatic students. Two qPCR) assay, a duplex qPCR assay, and sequencing were performed to determine the pathogen, genotype and macrolide resistance at the gene level, respectively. RESULTS: From May 1st to June 31st, 2018, we identified 55 cases (36 probable and 19 confirmed), of whom 25 (45%) were hospitalized for complications. All cases were students, none of the teachers and other staffs in the school were with similar symptoms. The attack rate (AR) was 3.9% (55/1398) for all students. The cases were mainly male (58%), with an age range of 7–8 years (median: 7 years). 72% (18/25) of inpatients had radiograph findings consistent with pneumonia, and some cases were hospitalized for up to 4 weeks. Pathogen detection results indicated that Mycoplasma pneumonia (M. pneumoniae) P1 type 1 was the causative agent in this outbreak, and the strain harbored one point mutation of A to G at position 2063. CONCLUSIONS: The infections by macrolide-resistant M. pneumoniae are not always mild and pneumonia was common and M. pneumoniae could causes serious complications which require long-term hospitalization. In the future infectious disease prevention and control practice, M. pneumoniae should be paid more attention. It is necessary to establish and improve the pathogen and drug resistance surveillance system in order to prevent and control such mutated strains of M. pneumoniae from causing future outbreaks or epidemics in China.
has issue date	2019-10-22(xsd:dateTime)
bibo:doi	10.1186/s12879-019-4473-6
bibo:pmid	31640591
has license	cc-by
sha1sum (hex)	357d43fba827a0d33c5810a56e193149df4777f7
schema:url	https://doi.org/10.1186/s12879-019-4473-6
resource representing a document's title	Outbreak of macrolide-resistant mycoplasma pneumoniae in a primary school in Beijing, China in 2018
has PubMed Central identifier	PMC6805422
has PubMed identifier	31640591
schema:publication	BMC Infect Dis
resource representing a document's body	covid:357d43fba827a0d33c5810a56e193149df4777f7#body_text
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