About: Phage display as a promising approach for vaccine development

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Phage display as a promising approach for vaccine development
Creator	Aghebati-Maleki, Ali Aghebati-Maleki, Leili Bakhshinejad, Babak Baradaran, Behzad Majidi, Jafar Motallebnezhad, Morteza Nickho, Hamid Yousefi, Mehdi
source	Medline; PMC
abstract	Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being highly stable under harsh environmental conditions, simple and inexpensive large scale production, and potent adjuvant capacities. Phage vaccines have efficient immunostimulatory effects and present a high safety profile because these viruses have made a constant relationship with the mammalian body during a long-standing evolutionary period. The birth of phage display technology has been a turning point in the development of phage-based vaccines. Phage display vaccines are made by expressing multiple copies of an antigen on the surface of immunogenic phage particles, thereby eliciting a powerful and effective immune response. Also, the ability to produce combinatorial peptide libraries with a highly diverse pool of randomized ligands has transformed phage display into a straightforward, versatile and high throughput screening methodology for the identification of potential vaccine candidates against different diseases in particular microbial infections. These libraries can be conveniently screened through an affinity selection-based strategy called biopanning against a wide variety of targets for the selection of mimotopes with high antigenicity and immunogenicity. Also, they can be panned against the antiserum of convalescent individuals to recognize novel peptidomimetics of pathogen-related epitopes. Phage display has represented enormous promise for finding new strategies of vaccine discovery and production and current breakthroughs promise a brilliant future for the development of different phage-based vaccine platforms.
has issue date	2016-09-29(xsd:dateTime)
bibo:doi	10.1186/s12929-016-0285-9
bibo:pmid	27680328
has license	cc-by
sha1sum (hex)	35fd455662a4a9c03d3791ee3a390c163a53f242
schema:url	https://doi.org/10.1186/s12929-016-0285-9
resource representing a document's title	Phage display as a promising approach for vaccine development
has PubMed Central identifier	PMC5041315
has PubMed identifier	27680328
schema:publication	J Biomed Sci
resource representing a document's body	covid:35fd455662a4a9c03d3791ee3a390c163a53f242#body_text
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