About: Severe Childhood Malaria Syndromes Defined by Plasma Proteome Profiles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe Childhood Malaria Syndromes Defined by Plasma Proteome Profiles
Creator	Athanasakis, Dimitrios Battaglia, Francesca Fernandez-Reyes, Delmiro Akinkunmi, Francis Burté, Florence Kowobari, Olayinka Omokhodion, Samuel Osinusi, Kikelomo Sodeinde, Olugbemiro Ely, Barry Afolabi, Nathaniel Ajetunmobi, Wasiu Akinbami, Felix Brown, Biobele Orimadegun, Adebola Shokunbi, Wuraola
Source	PMC
abstract	BACKGROUND: Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood. Therefore it is important to understand the pathology underlying the development of CM and SMA, as opposed to uncomplicated malaria (UM). Different host responses to infection are likely to be reflected in plasma proteome-patterns that associate with clinical status and therefore provide indicators of the pathogenesis of these syndromes. METHODS AND FINDINGS: Plasma and comprehensive clinical data for discovery and validation cohorts were obtained as part of a prospective case-control study of severe childhood malaria at the main tertiary hospital of the city of Ibadan, an urban and densely populated holoendemic malaria area in Nigeria. A total of 946 children participated in this study. Plasma was subjected to high-throughput proteomic profiling. Statistical pattern-recognition methods were used to find proteome-patterns that defined disease groups. Plasma proteome-patterns accurately distinguished children with CM and with SMA from those with UM, and from healthy or severely ill malaria-negative children. CONCLUSIONS: We report that an accurate definition of the major childhood malaria syndromes can be achieved using plasma proteome-patterns. Our proteomic data can be exploited to understand the pathogenesis of the different childhood severe malaria syndromes.
has issue date	2012-12-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0049778
bibo:pmid	23226502
has license	cc-by
sha1sum (hex)	3695704554777889f8232a9ea086df70bf17ff58
schema:url	https://doi.org/10.1371/journal.pone.0049778
resource representing a document's title	Severe Childhood Malaria Syndromes Defined by Plasma Proteome Profiles
has PubMed Central identifier	PMC3514223
has PubMed identifier	23226502
schema:publication	PLoS One
resource representing a document's body	covid:3695704554777889f8232a9ea086df70bf17ff58#body_text
is schema:about of	named entity 'infection' named entity 'indicators' named entity 'SMA' named entity 'host' named entity 'falciparum' named entity 'Plasma' named entity 'Defined' named entity 'PLASMA' named entity 'PATHOGENESIS' named entity 'CLINICAL SYNDROMES' named entity 'REFLECTED' named entity 'HOST' named entity 'DEVELOPMENT' named entity 'PATHOLOGY' named entity 'UNDERLYING' named entity 'PROVIDE' named entity 'SYNDROMES' named entity 'DIFFERENT' named entity 'DEFINED' named entity 'SEVERE' named entity 'INDICATORS' named entity 'CLINICAL STATUS' named entity 'MALARIA' named entity 'PROTEOME' named entity 'SEVERE MALARIAL ANEMIA' named entity 'SYNDROMES' named entity 'CHILDHOOD' named entity 'MALARIA' named entity 'PLASMA' named entity 'PROTEOME' named entity 'UNDERSTAND' named entity 'CEREBRAL MALARIA' named entity 'UNCOMPLICATED' named entity 'CHILDHOOD' named entity 'ASSOCIATE' named entity 'PATTERNS' named entity 'LIKELY' named entity 'THESE' named entity 'SMA' named entity 'IMPORTANT' named entity 'RESPONSES' named entity 'PLASMODIUM FALCIPARUM INFECTION' named entity 'BACKGROUND' named entity 'LIFE' named entity 'INFECTION' covid:arg/3695704554777889f8232a9ea086df70bf17ff58 named entity 'plasma' named entity 'anemia' named entity 'development' named entity 'Cerebral malaria' named entity 'Proteome' named entity 'pathogenesis' named entity 'Plasmodium falciparum infection' named entity 'life-threatening' named entity 'SMA' named entity 'uncomplicated malaria' named entity 'Proteome' named entity 'Malaria' named entity 'BioRad' named entity 'plasma' named entity 'WHO' named entity 'm/z' named entity 'Peptide' named entity 'Disease Control' named entity 'University of Ibadan' named entity 'malaria'

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