About: Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway

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About: Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway
Creator	Herrler, Georg Ren, Xiaofeng Ren, Yudong Li, Guangxing Cao, Liyan Gao, Yu Ge, Xuying
Source	Medline; PMC
abstract	BACKGROUND: The lack of optimal porcine cell lines has severely impeded the study and progress in elucidation of porcine epidemic diarrhea virus (PEDV) pathogenesis. Vero cell, an African green monkey kidney cell line, was often used to isolate and propagate PEDV. Nonetheless, the target cells of PEDV in vivo are intestinal epithelial cells, during infection, intestinal epithelia would be damaged and resulted in digestive disorders. The immune functions of porcine epithelial cells and interactions with other immune cell populations display a number of differences compared to other species. Type I interferon (IFN) plays an important role in antiviral immune response. Limited reports showed that PEDV could inhibit type I interferon production. In this study, porcine small intestinal epithelial cells (IECs), the target cells of PEDV, were used as the infection model in vitro to identify the possible molecular mechanisms of PEDV-inhibition IFN-β production. RESULTS: PEDV not only failed to induce IFN-β expression, but also inhibited dsRNA-mediated IFN-β production in IECs. As the key IFN-β transcription factors, we found that dsRNA-induced activation of IFN regulatory factor 3 (IRF-3) was inhibited after PEDV infection, but not nuclear factor-kappaB (NF-κB). To identify the mechanism of PEDV intervention with dsRNA-mediated IFN-β expression more accurately, the role of individual molecules of RIG-I signaling pathway were investigated. In the upstream of IRF-3, TANK-binding kinase 1 (TBK1)-or inhibitor of κB kinase-ε (IKKε)-mediated IFN-β production was not blocked by PEDV, while RIG-I-and its adapter molecule IFN-β promoter stimulator 1 (IPS-1)-mediated IFN-β production were completely inhibited after PEDV infection. CONCLUSION: Taken together, our data demonstrated for the first time that PEDV infection of its target cell line, IECs, inhibited dsRNA-mediated IFN-β production by blocking the activation of IPS-1 in RIG-I-mediated pathway. Our studies offered new visions in understanding of the interaction between PEDV and host innate immune system.
has issue date	2015-08-18(xsd:dateTime)
bibo:doi	10.1186/s12985-015-0345-x
bibo:pmid	26283628
has license	cc-by
sha1sum (hex)	384cdcda67c8a385d6a571ba5f9fb09e16d130b5
schema:url	https://doi.org/10.1186/s12985-015-0345-x
resource representing a document's title	Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway
has PubMed Central identifier	PMC4539884
has PubMed identifier	26283628
schema:publication	Virol J
resource representing a document's body	covid:384cdcda67c8a385d6a571ba5f9fb09e16d130b5#body_text
is schema:about of	named entity 'DSRNA' named entity 'Limited' named entity 'pathogenesis' named entity 'porcine' named entity 'RIG-I' named entity 'INTESTINAL' named entity 'DISPLAY' named entity 'CELL LINES' named entity 'INTERFERON ' named entity 'INTERACTIONS' named entity 'ANTIVIRAL IMMUNE RESPONSE' named entity 'ROLE' named entity 'DIGESTIVE DISORDERS' named entity 'PORCINE' named entity 'OPTIMAL' named entity 'IMMUNE' named entity 'IMMUNE CELL' named entity 'TYPE I INTERFERON' named entity 'IN VIVO' named entity 'IMPORTANT' named entity 'FUNCTIONS' named entity 'SPECIES' named entity 'LIMITED' named entity 'BACKGROUND' named entity 'TYPE I INTERFERON PRODUCTION' named entity 'IMPEDED' named entity 'SMALL INTESTINAL' named entity 'REPORTS' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'INDUCED' named entity 'USED' named entity 'SEVERELY' named entity 'TARGET CELLS' named entity 'DAMAGED' named entity 'PATHOGENESIS' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'STUDY' named entity 'COMPARED' named entity 'PATHWAY' named entity 'IFN' named entity 'EPITHELIAL CELLS' named entity 'BLOCKADE' named entity 'MEDIATED' named entity 'VERO CELL' named entity 'INHIBITION' named entity 'INFECTION' named entity 'LACK' named entity 'PROGRESS' named entity 'TO IDENTIFY' named entity 'AFRICAN GREEN MONKEY' named entity 'PRODUCTION' named entity 'IN VITRO' named entity 'PLAYS' named entity 'MECHANISMS' named entity 'KIDNEY CELL LINE' named entity 'POPULATIONS' named entity 'INTERFERON' named entity 'PRODUCTION' named entity 'PORCINE' named entity 'INFECTION MODEL' named entity 'POSSIBLE' named entity 'ISOLATE' named entity 'INTESTINAL' named entity 'NUMBER OF' named entity 'MOLECULAR' named entity 'EPITHELIAL CELLS' covid:arg/384cdcda67c8a385d6a571ba5f9fb09e16d130b5 named entity 'IFN' named entity 'small intestinal' named entity 'optimal' named entity 'target cells' named entity 'target cells' named entity 'infection' named entity 'intestinal epithelial cells' named entity 'porcine'

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