About: Calf-Level Factors Associated with Bovine Neonatal Pancytopenia

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About: Calf-Level Factors Associated with Bovine Neonatal Pancytopenia – A Multi-Country Case-Control Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Calf-Level Factors Associated with Bovine Neonatal Pancytopenia – A Multi-Country Case-Control Study
Creator	Booth, Richard De Vliegher, Sarne Deprez, Piet Fourichon, Christine Guatteo, Raphael Henning, Joerg Laureyns, Jozef Nielen, Mirjam Nusinovici, Simon Sauter-Louis, Carola Schouten, Matthijs Smolenaars, Anja Stoll, Alexander Pfeiffer, Dirk Cardwell, Jackie Jones, Bryony Auré, Lien Den Uijl, Ingrid Madouasse, Schaik, Gerdien
source	Medline; PMC
abstract	Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up to four calves of similar age from the same farm were selected as controls (1154 calves). Risk factor data were collected by questionnaire. Multivariable modelling using conditional logistic regression indicated that PregSure®BVD (PregSure, Pfizer Animal Health) vaccination of the dam was strongly associated with BNP cases (adjusted matched Odds Ratio - amOR 17.8 first lactation dams; 95% confidence interval – ci 2.4, 134.4; p = 0.005), and second or more lactation PregSure-vaccinated dams were more likely to have a case than first lactation vaccinated dams (amOR 2.2 second lactation; ci 1.1, 4.3; p = 0.024; amOR 5.3 third or more lactation; ci 2.9, 9.8; p = <0.001). Feeding colostrum from other cows was strongly associated with BNP if the dam was not PregSure-vaccinated (amOR 30.5; ci 2.1, 440.5; p = 0.012), but the effect was less if the dam was PregSure-vaccinated (amOR 2.1; ci 1.1, 4.0; p = 0.024). Feeding exclusively dam’s milk was a higher risk than other types of milk (amOR 3.4; ci 1.6, 7.5; p = 0.002). The population attributable fractions were 0.84 (ci 0.68, 0.92) for PregSure vaccination, 0.13 (ci 0.06, 0.19) for feeding other cows’ colostrum, and 0.15 (ci 0.08, 0.22) for feeding dam’s milk. No other calf-level factors were identified, suggesting that there are other important factors that are outside the scope of this study, such as genetics, which explain why BNP develops in some PregSure-colostrum-exposed calves but not in others.
has issue date	2013-12-02(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0080619
bibo:pmid	24312485
has license	cc-by
sha1sum (hex)	38eee3781e1192464696b9a1164834259214cde9
schema:url	https://doi.org/10.1371/journal.pone.0080619
resource representing a document's title	Calf-Level Factors Associated with Bovine Neonatal Pancytopenia – A Multi-Country Case-Control Study
has PubMed Central identifier	PMC3846664
has PubMed identifier	24312485
schema:publication	PLoS One
resource representing a document's body	covid:38eee3781e1192464696b9a1164834259214cde9#body_text
is schema:about of	named entity 'SELECTED' named entity 'CASE-CONTROL STUDY' named entity 'LEVEL' named entity 'COUNTRIES' named entity 'LOW' named entity 'REPORTED' named entity 'FARMS' named entity '4.3' named entity 'NEW ZEALAND' named entity 'PANCYTOPENIA' named entity 'FEEDING' named entity 'COLLECTED BY' named entity 'OUTSIDE' named entity 'TYPES' named entity 'NEONATAL' named entity 'ODDS RATIO' named entity 'MATCHED CASE-CONTROL STUDY' named entity 'COLOSTRUM' named entity 'PFIZER' named entity 'CONDITIONAL' named entity 'EUROPEAN' named entity 'FRACTIONS' named entity '330' named entity 'SCOPE' named entity 'INCIDENCE' named entity 'DEVELOPS' named entity '2.1' named entity 'LACTATION' named entity 'BUT' named entity 'EFFECT' named entity 'OBSERVED' named entity 'IDENTIFIED' named entity 'CAUSING' named entity 'CITATION' named entity '405' named entity 'DATA' named entity '2.9' named entity 'EXPOSED' named entity 'MATCHED' named entity 'ATTRIBUTABLE' named entity '0.15' named entity 'cows' named entity 'causing' named entity 'Animal Health' named entity 'weeks' named entity 'Odds' named entity 'PLoS ONE' named entity 'feeding' named entity 'incidence' named entity 'dam' named entity 'observed' named entity 'Risk factor' named entity 'Biology' covid:arg/38eee3781e1192464696b9a1164834259214cde9 named entity '2.4' named entity 'INDICATED' named entity 'USING' named entity 'MILK' named entity '2.2' named entity '1.1' named entity 'UP TO' named entity 'AGED'

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