About: SARS‐associated viral hepatitis caused by a novel coronavirus: Report of three cases

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: SARS‐associated viral hepatitis caused by a novel coronavirus: Report of three cases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS‐associated viral hepatitis caused by a novel coronavirus: Report of three cases
Creator	Chau, Tai-Nin Choi, Kin-Wing Lai, Sik-To Lee, Kam-Cheong Tso, Yuk-Keung Tsang, Tak-Yin Lau, Terence Yao, Hung Chow, Tat-Chong Lai, Ching-Lung Yeung, Yiu-Cheong
Source	Medline; PMC
abstract	Liver impairment is commonly reported in up to 60% of patients who suffer from severe acute respiratory syndrome (SARS). Here we report the clinical course and liver pathology in three SARS patients with liver impairment. Three patients who fulfilled the World Health Organization case definition of probable SARS and developed marked elevation of alanine aminotransferase were included. Percutaneous liver biopsies were performed. Liver specimens were examined by light and electron microscopy, and immunohistochemistry. Reverse‐transcriptase polymerase chain reaction (RT‐PCR) using enhanced real‐time PCR was applied to look for evidence of SARS‐associated coronavirus infection. Marked accumulation of cells in mitosis was observed in two patients and apoptosis was observed in all three patients. Other common pathologic features included ballooning of hepatocytes and mild to moderate lobular lymphocytic infiltration. No eosinophilic infiltration, granuloma, cholestasis, fibrosis, or fibrin deposition was noted. Immunohistochemical studies revealed 0.5% to 11.4% of nuclei were positive for proliferative antigen Ki‐67. RT‐PCR showed evidence of SARS‐associated coronavirus in the liver tissues, but not in the sera of all 3 patients. However, electron microscopy could not identify viral particles. No giant mitochondria, micro‐ or macro‐vesicular steatosis was observed. In conclusion, hepatic impairment in patients with SARS is due to SARS‐associated coronavirus infection of the liver. The prominence of mitotic activity of hepatocytes is unique and may be due to a hyperproliferative state with or without disruption of cell cycle by the coronavirus. With better knowledge of pathogenesis, specific therapy may be targeted to reduce viral replication and modify the disease course. (Hepatology 2004;39:302–310.)
has issue date	2004-01-30(xsd:dateTime)
bibo:doi	10.1002/hep.20111
bibo:pmid	14767982
has license	no-cc
sha1sum (hex)	3978d290c211ecc71d81135b6778a9378f54b8cb
schema:url	https://doi.org/10.1002/hep.20111
resource representing a document's title	SARS‐associated viral hepatitis caused by a novel coronavirus: Report of three cases
has PubMed Central identifier	PMC7165792
has PubMed identifier	14767982
schema:publication	Hepatology
resource representing a document's body	covid:3978d290c211ecc71d81135b6778a9378f54b8cb#body_text
is schema:about of	named entity 'infection' named entity 'patients' named entity 'World Health Organization' named entity 'moderate' named entity 'positive' named entity 'features' named entity 'infiltration' named entity 'RT-PCR' named entity 'Ki-67' named entity 'Three' named entity 'PERCUTANEOUS' named entity 'MAY BE' named entity 'IMPAIRMENT' named entity 'LYMPHOCYTIC INFILTRATION' named entity 'BALLOONING OF HEPATOCYTES' named entity 'KNOWLEDGE' named entity 'CELL CYCLE' covid:arg/3978d290c211ecc71d81135b6778a9378f54b8cb named entity 'fibrosis' named entity 'liver' named entity 'SARS-associated coronavirus' named entity 'electron microscopy' named entity 'specimens' named entity 'impairment' named entity 'reduce' named entity 'Three' named entity 'hepatic impairment' named entity 'mitochondria' named entity 'real-time PCR' named entity 'electron microscopy' named entity 'immunohistochemistry' named entity 'coronavirus' named entity 'SARS' named entity 'SARS-associated coronavirus' named entity 'Ki-67' named entity 'nuclei' named entity 'World Health Organization' named entity 'Liver' named entity 'liver' named entity 'polymerase chain reaction' named entity 'cholestasis' named entity 'granuloma' named entity 'liver impairment' named entity 'lymphocytic infiltration' named entity 'SARS' named entity 'Convalescent serum' named entity 'Belgium' named entity 'ritonavir' named entity 'random hexamer' named entity 'clarithromycin' named entity 'lung' named entity 'Hamburg' named entity 'gene' named entity 'lipid' named entity 'coronavirus' named entity 'informed consent' named entity 'cytopathic effect' named entity 'mitochondria' named entity 'antibodies' named entity 'acidophilic' named entity 'SARS-CoV' named entity 'SARS' named entity '2.6' named entity 'SARS' named entity 'lopinavir' named entity 'liver' named entity 'liver impairment' named entity 'fibrosis' named entity 'immunofluorescent' named entity 'ribavirin' named entity 'pneumonia'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software