About: Gene Expression Network Analysis Provides Potential Targets Against SARS-CoV-2

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gene Expression Network Analysis Provides Potential Targets Against SARS-CoV-2
Creator	Bossé4, Yohan Hao8, Don Hernández Cordero1, Ana Joubert4, Wim Li1, Xuan Milne1, Stephen Nickle7, Ke Sin1, Timens5, Maarten Van Den Berge6, David Yang1, Chen
Source	BioRxiv
abstract	BACKGROUND Cell entry of SARS-CoV-2, the novel coronavirus causing COVID-19, is facilitated by host cell angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). We aimed to identify and characterize genes that are co-expressed with ACE2 and TMPRSS2, and to further explore their biological functions and potential as druggable targets. METHODS Using the gene expression profiles of 1,038 lung tissue samples, we performed a weighted gene correlation network analysis (WGCNA) to identify modules of co-expressed genes. We explored the biology of co-expressed genes using bioinformatics databases, and identified known drug-gene interactions. RESULTS ACE2 was in a module of 681 co-expressed genes; 12 genes with moderate-high correlation with ACE2 (r>0.3, FDR<0.05) had known interactions with existing drug compounds. TMPRSS2 was in a module of 1,086 co-expressed genes; 15 of these genes were enriched in the gene ontology biologic process ‘Entry into host cell’, and 53 TMPRSS2-correlated genes had known interactions with drug compounds. CONCLUSION Dozens of genes are co-expressed with ACE2 and TMPRSS2, many of which have plausible links to COVID-19 pathophysiology. Many of the co-expressed genes are potentially targetable with existing drugs, which may help to fast-track the development of COVID-19 therapeutics.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1101/2020.07.06.182634
has license	biorxiv
sha1sum (hex)	3acbf9fcbddcc119d8788e69f5df3604697e3df2
schema:url	https://doi.org/10.1101/2020.07.06.182634
resource representing a document's title	Gene Expression Network Analysis Provides Potential Targets Against SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:3acbf9fcbddcc119d8788e69f5df3604697e3df2#body_text
is schema:about of	named entity 'TMPRSS2' named entity 'RESULTS' named entity 'databases' named entity 'genes' named entity 'network analysis' named entity 'ACE2' named entity 'drugs' named entity 'TMPRSS2' named entity 'genes' named entity 'smokers' named entity 'KNOWN' named entity 'THEIR' named entity 'HELP' named entity 'PATHOPHYSIOLOGY' named entity 'gene ontology' named entity 'gene' named entity 'interactions' named entity 'biologic' named entity 'TMPRSS2' named entity 'Hypertension' named entity 'explored' named entity 'genes' named entity 'expression profiles' named entity 'identify' named entity 'gene ontology' named entity 'Hypertension' named entity 'Cell entry' named entity 'coronavirus' named entity 'Cardiac disease' named entity 'smokers' named entity 'gene interactions' named entity 'SARS-CoV-2' named entity 'gene expression profiles' named entity 'expressed genes' named entity 'correlation' named entity 'expressed genes' named entity 'risk factor' named entity 'HDAC8' named entity 'ACE2' named entity 'Mouse Genome Informatics' named entity 'ACE2' named entity 'COVID' named entity 'TMPRSS2' named entity 'ACE2' named entity 'TMPRSS2' named entity 'ComBat' named entity 'MGI' named entity 'TMPRSS2' named entity 'type 1' named entity 'ACE2' named entity 'set of genes' named entity 'angiotensin II' named entity 'hypertension' named entity 'gene' named entity 'OMIM' named entity 'viral entry' named entity 'knockout mouse' named entity 'gene expression' named entity 'COVID' named entity 'Mendelian Inheritance in Man' named entity 'human diseases' named entity 'risk factor' named entity 'ACE2' named entity 'complement' named entity 'host cell' named entity 'gene interactions' named entity 'ACE2' named entity 'gene' named entity 'expressed genes' named entity 'drug targets' named entity 'interact' named entity 'COPD' named entity 'pathogenesis' named entity 'TMPRSS2'

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