About: Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro
Creator	Cao, Yang Shu, Yuelong Li, Zi Zhou, Jianfang Qin, Kun Xin, Li Guo, Jinlei Wang, Donghong Zhao, Xiaopeng
Source	Elsevier; Medline; PMC
abstract	Abstract Mannose-binding lectin (MBL), a pattern-recognition molecule in serum, recognizes specific hexose sugars rich in mannose and N-acetylglucosamine on bacterium, yeasts, viruses as well as apoptotic cells. It has been well-identified that MBL has antiviral effects via binding to seasonal influenza H1 and H3 subtype viruses. Influenza A (H7N9) virus, a novel reassortant virus to human population, possesses the surface hemagglutinin (HA) and neuraminidase (NA) genes from duck and wild-bird influenza viruses and internal genes from poultry H9N2 viruses. As of Dec 7th, 2014, a total of 467 human infections and 183 fatal cases have been identified. Here, recombinant human (rh) MBL was tested for its binding and effects on hemagglutination inhibition (HI) and NA activity inhibition (NAI) of avian H7N9, H9N2 and human H3N2 viruses. We discovered that rhMBL exhibited a strong binding to H7N9 virus as human H3N2 did at high virus titers. However, it performed a significantly weaker HI activity effect on H7N9 comparing to those of H3N2 and H9N2, even at a much higher concentration (3.67 ± 0.33 vs. 0.026 ± 0.001 and 0.083 ± 0.02 μg/mL, respectively). Similarly, minor NAI effect of rhMBL, even at up to 10 μg/mL, was found on H7N9 virus while it displayed significant effects on both H3N2 and H9N2 at a lowest concentration of 0.0807 ± 0.009 and 0.0625 μg/mL, respectively. The HI and NAI effects of rhMBL were calcium-dependent and mediated by lectin domain. Our findings suggest that MBL, the host innate molecule, has differential interference effects with human and avian influenza virus and limited antiviral effect against H7N9 virus.
has issue date	2015-02-27(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2015.01.070
bibo:pmid	25634695
has license	els-covid
sha1sum (hex)	3c54d2a79a4b63fa6dde823622d4196e21e04e37
schema:url	https://doi.org/10.1016/j.bbrc.2015.01.070
resource representing a document's title	Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro
has PubMed Central identifier	PMC7092832
has PubMed identifier	25634695
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:3c54d2a79a4b63fa6dde823622d4196e21e04e37#body_text
is schema:about of	named entity 'VIRUS' named entity 'effects' named entity 'human population' named entity 'binding' named entity 'strong' named entity 'NAI' covid:arg/3c54d2a79a4b63fa6dde823622d4196e21e04e37 named entity 'RECOGNITION' named entity 'NOVEL' named entity 'N-ACETYLGLUCOSAMINE' named entity 'CASES' named entity 'HEMAGGLUTINATION INHIBITION' named entity 'HUMAN POPULATION' named entity 'ITS' named entity 'RECOMBINANT' named entity 'IDENTIFIED' named entity 'HEMAGGLUTININ' named entity 'SERUM' named entity 'STRONG' named entity 'MBL' named entity 'H7N9' named entity 'HIGH' named entity 'SUGARS' named entity 'INHIBITION' named entity 'TESTED FOR' named entity 'SEASONAL INFLUENZA' named entity 'BIRD' named entity 'BINDING' named entity '283' named entity 'TOTAL' named entity 'MANNOSE-BINDING LECTIN' named entity '183' named entity 'RECOMBINANT HUMAN MANNOSE-BINDING LECTIN' named entity 'EFFECT' named entity 'NOVEL' named entity 'NEURAMINIDASE' named entity 'DUCK' named entity 'COMPARING' named entity 'IN VITRO' named entity 'INFECTION' named entity 'LIMITED' named entity '0.33' named entity 'ACTIVITY' named entity 'VIRUSES' named entity 'INFLUENZA A' named entity 'POULTRY' named entity 'WILD' named entity 'SURFACE' named entity 'A PATTERN' named entity 'DEC' named entity 'SPECIFIC' named entity 'POSSESSES' named entity 'VIRUS' named entity 'INFECTIONS' named entity 'MUCH' named entity 'HEXOSE' named entity 'HAVE' named entity 'INFLUENZA A' named entity 'SUBTYPE' named entity 'ANTIVIRAL' named entity 'FATAL' named entity 'EFFECTS' named entity 'AVIAN' named entity '7TH' named entity 'HUMAN' named entity 'APOPTOTIC' named entity 'BACTERIUM' named entity 'RICH' named entity 'YEASTS' named entity 'GENES' named entity 'CELLS' named entity 'DID' named entity 'HERE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software