About: Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus

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About: Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus
Creator	Arbogast, Andrew Fleming, Damarius Guo, Baoqing Yang, Han-Chun Henningson, Jamie Lager, Kelly Miller, Laura Bayles, Darrell Faaberg, Kay Kehrli, Marcus Schlink, Sarah
source	Medline; PMC
abstract	BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen of swine worldwide. Emergence in 2006 of a novel highly pathogenic PRRSV (HP-PRRSV) isolate in China necessitated a comparative investigation into the host transcriptome response in tracheobronchial lymph nodes (TBLN) 13 days post-infection with HP-PRRSV rJXwn06, PRRSV strain VR-2332 or sham inocula. RNA from each was prepared for next-generation sequencing. Amplified library constructs were directly sequenced and a list of sequence transcripts and counts was generated using an RNAseq analysis pipeline to determine differential gene expression. Transcripts were annotated and relative abundance was calculated based upon the number of times a given transcript was represented in the library. RESULTS: Major changes in transcript abundance occurred in response to infection with either PRRSV strain, each with over 630 differentially expressed transcripts. The largest increase in transcript level for either virus versus sham-inoculated controls were three serum amyloid A2 acute-phase isoforms. However, the degree of up or down-regulation of transcripts following infection with HP-PRRSV rJXwn06 was greater than transcript changes observed with US PRRSV VR-2332. Also, of 632 significantly altered transcripts within the HP-PRRSV rJXwn06 library 55 were up-regulated and 69 were down-regulated more than 3-fold, whilst in the US PRRSV VR-2332 library only 4 transcripts were up-regulated and 116 were down-regulated more than 3-fold. CONCLUSIONS: The magnitude of differentially expressed gene profiles detected in HP-PRRSV rJXwn06 infected pigs as compared to VR-2332 infected pigs was consistent with the increased pathogenicity of the HP-PRRSV in vivo.
has issue date	2012-10-30(xsd:dateTime)
bibo:doi	10.1186/1746-6148-8-208
bibo:pmid	23110781
has license	cc-by
sha1sum (hex)	3c8a38879c8d9910167b2dab37c2d98e17701141
schema:url	https://doi.org/10.1186/1746-6148-8-208
resource representing a document's title	Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus
has PubMed Central identifier	PMC3514351
has PubMed identifier	23110781
schema:publication	BMC Vet Res
resource representing a document's body	covid:3c8a38879c8d9910167b2dab37c2d98e17701141#body_text
is schema:about of	named entity 'annotated' named entity 'RNA' named entity 'respiratory' named entity 'INFECTION' named entity 'SWINE' named entity 'RESPONSE' named entity 'SEQUENCE' named entity 'SWINE' named entity 'ANALYSIS' named entity 'RESPONSE TO' named entity 'CHINESE' named entity 'DIFFERENTIAL GENE EXPRESSION' named entity 'WORLDWIDE' covid:arg/3c8a38879c8d9910167b2dab37c2d98e17701141 named entity 'TRACHEOBRONCHIAL LYMPH NODES' named entity 'A MAJOR' named entity 'PATHOGENIC' named entity 'PIPELINE' named entity 'ANNOTATED' named entity 'LIST' named entity 'STRAIN' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'BASED' named entity 'CHINA' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'DETERMINE' named entity 'BACKGROUND' named entity 'AMPLIFIED' named entity 'PATHOGENIC' named entity 'TRACHEOBRONCHIAL LYMPH NODE' named entity 'HIGHLY' named entity 'SHAM' named entity 'ISOLATE' named entity 'INVESTIGATION' named entity 'NEXT-GENERATION SEQUENCING' named entity 'IS A' named entity 'TRANSCRIPTOME' named entity 'RNA' named entity 'HIGHLY' named entity 'TRANSCRIPTS' named entity 'GENERATED' named entity 'NUMBER OF TIMES' named entity 'RELATIVE ABUNDANCE' named entity 'TRANSCRIPT' named entity 'STRAIN' named entity 'NOVEL' named entity 'USING' named entity 'DAYS' named entity 'RNASEQ' named entity 'POST' named entity 'DIRECTLY' named entity 'GIVEN' named entity 'CALCULATED' named entity 'LIBRARY' named entity 'PREPARED' named entity 'HOST' named entity 'COUNTS' named entity 'EMERGENCE' named entity 'ANALYSIS' named entity 'INFECTION' named entity 'PATHOGEN' named entity 'sequenced' named entity 'counts' named entity 'determine' named entity 'list' named entity 'transcriptomic' named entity 'RNA' named entity 'differential gene expression' named entity 'tracheobronchial lymph nodes' named entity 'swine' named entity 'S100'

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