About: Arenavirus Diversity and Evolution: Quasispecies In Vivo

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Arenavirus Diversity and Evolution: Quasispecies In Vivo
Creator	De La Torre, J Sevilla, N
Source	Medline; PMC
abstract	Arenaviruses exist as viral quasispecies due to the high mutation rates of the low-fidelity viral RNA-dependent RNA polymerase (RdRp). This genomic heterogeneity is advantageous to the population, allowing for adaptation to rapidly changing environments that present varying types and degrees of selective pressure. The significant variation in biological properties observed among lymphocytic choriomeningitis virus (LCMV) strains, the prototypic arenavirus, indicates to what extent a quasispecies dynamics may play a role in arenavirus adaptability and pathogenesis. Several aspects of arenavirus variability and its contribution to pathogenesis will be discussed.
has issue date	2006-01-01(xsd:dateTime)
bibo:doi	10.1007/3-540-26397-7_11
bibo:pmid	16568904
has license	no-cc
sha1sum (hex)	3ebb8bee25266c7bb55cdb989ac577a23c7065ce
schema:url	https://doi.org/10.1007/3-540-26397-7_11
resource representing a document's title	Arenavirus Diversity and Evolution: Quasispecies In Vivo
has PubMed Central identifier	PMC7120374
has PubMed identifier	16568904
schema:publication	Quasispecies: Concept and Implications for Virology
resource representing a document's body	covid:3ebb8bee25266c7bb55cdb989ac577a23c7065ce#body_text
is schema:about of	named entity 'Quasispecies' named entity 'virus' named entity 'bottleneck' named entity 'macrophages' named entity 'amino acid' named entity 'viruses' named entity 'error correction' named entity 'negative strand' named entity 'Sequence analysis' named entity 'RdRp' named entity 'CTL' named entity 'biological properties' named entity 'GHDS' named entity 'spleen' named entity 'phenotype' named entity 'reassortants' named entity 'ligands' named entity 'infection' named entity 'amino acid' named entity 'RNA-dependent RNA polymerase' named entity 'infection' named entity 'receptor' named entity 'phenotypic' named entity 'infection' named entity 'arenavirus' named entity 'evolution' named entity 'amino acid' named entity 'nucleotide change' named entity 'GHDS' named entity 'CD8 +' named entity 'ambisense' named entity 'GHDS' named entity 'spleen' named entity 'LCMV' named entity 'GP2' named entity 'Ciurea' named entity 'GHDS' named entity 'virologic' named entity 'RdRp' named entity 'Phe' named entity 'viral quasispecies' named entity 'high-affinity' named entity 'RNA' named entity 'LCMV' named entity 'substrates' named entity 'virus' named entity 'dendritic cells' named entity 'virus' named entity 'evolution' named entity 'infection' named entity 'wild-type' named entity 'Virus' named entity 'viruses' named entity 'mice' named entity 'nucleotide' named entity 'mice' named entity 'macrophages' named entity 'immunocompetent' named entity 'CTL' named entity 'immunosuppressive' named entity 'uterus' named entity 'RNA viruses' named entity 'chronicity' named entity 'protein production' named entity 'neonatal infection' named entity 'Sevilla' named entity 'reassortant' named entity 'physiological' named entity 'infection' named entity 'laboratory animal' named entity 'virus' named entity 'infection' named entity 'closely related' named entity 'immunosuppression' named entity 'viral infection' named entity 'reassortants' named entity 'selective pressure' named entity 'clonal analysis' named entity 'CNS' named entity 'CTL response'

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