About: SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase

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About: SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase
Creator	Bozzoni, Irene Santini, Tiziana Dimartino, Dacia Capparelli, Francesca Colantoni, Alessio Mariani, Davide Martone, Julie Morlando, Mariangela Paiardini, Alessandro Setti, Adriano Shamloo, Sama
Source	PMC
abstract	Guanine‐quadruplexes (G4) included in RNA molecules exert several functions in controlling gene expression at post‐transcriptional level; however, the molecular mechanisms of G4‐mediated regulation are still poorly understood. Here, we describe a regulatory circuitry operating in the early phases of murine muscle differentiation in which a long non‐coding RNA (SMaRT) base pairs with a G4‐containing mRNA (Mlx‐γ) and represses its translation by counteracting the activity of the DHX36 RNA helicase. The time‐restricted, specific effect of lnc‐SMaRT on the translation of Mlx‐γ isoform modulates the general subcellular localization of total MLX proteins, impacting on their transcriptional output and promoting proper myogenesis and mature myotube formation. Therefore, the circuitry made of lnc‐SMaRT, Mlx‐γ, and DHX36 not only plays an important role in the control of myogenesis but also unravels a molecular mechanism where G4 structures and G4 unwinding activities are regulated in living cells.
has issue date	2020-04-26(xsd:dateTime)
bibo:doi	10.15252/embr.201949942
bibo:pmid	32337838
has license	cc-by
sha1sum (hex)	3eebc9b9add37f8b89a9b14a29f06b6cb55e9194
schema:url	https://doi.org/10.15252/embr.201949942
resource representing a document's title	SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase
has PubMed Central identifier	PMC7271651
has PubMed identifier	32337838
schema:publication	EMBO Rep
resource representing a document's body	covid:3eebc9b9add37f8b89a9b14a29f06b6cb55e9194#body_text
is schema:about of	named entity 'expression' named entity 'regulated' named entity 'structures' named entity 'lncRNA' named entity 'POST' named entity 'EXERT' named entity 'TRANSLATION' named entity 'INCLUDED' named entity 'MRNA' named entity 'RNA' named entity 'CONTROLLING GENE' named entity 'ACTIVITY' named entity 'THEIR' named entity 'TRANSCRIPTIONAL' covid:arg/3eebc9b9add37f8b89a9b14a29f06b6cb55e9194 named entity 'activity' named entity 'describe' named entity 'gene' named entity 'murine' named entity 'molecular' named entity 'operating' named entity 'base pairs' named entity 'isoform' named entity 'transcriptional' named entity 'gene expression' named entity 'post-transcriptional' named entity 'myogenesis' named entity 'myogenesis' named entity 'mRNA' named entity 'helicase' named entity 'G-quadruplex' named entity 'NGS' named entity 'lnc' named entity 'Thermo Scientific' named entity 'Illumina' named entity 'Protein' named entity 'pmol' named entity 'RPKM' named entity 'lnc' named entity 'penicillin' named entity 'RNA-Seq' named entity 'GAPDH' named entity 'muscle' named entity 'RNA' named entity '1:50' named entity 'RNA' named entity 'DAPI' named entity 'G-quadruplex' named entity 'lnc' named entity 'protein' named entity 'promoter sequence' named entity 'cytoplasmic' named entity 'lnc' named entity 'MyoD' named entity 'hybridizer' named entity 'MEF2C' named entity 'Roche' named entity 'secondary structures' named entity 'Thermo Scientific' named entity 'isoforms' named entity 'lnc' named entity 'myoblasts' named entity 'Italy' named entity 'fluorescent' named entity 'DHX36' named entity 'immunofluorescence' named entity 'pull-down' named entity 'nucleus' named entity 'antibodies' named entity 'myokines' named entity 'binary images'

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