About: Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones

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About: Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones
Creator	Neyts, Johan Naesens, Lieve Kumarasamy, Dhanabal Maity, Subhasis Mookerjee, Musfiqua Nanjappan, Satheeshkumar Rocha-Pereira, Joana Roy, Biswajit
Source	Elsevier; Medline; PMC
abstract	Abstract A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR, 1H NMR, 13C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and RNA viruses, along with assessment for potential cytotoxicity in diverse mammalian cell lines. Compound 4m, which possesses a long lipophilic side chain, was found to be a potent and selective inhibitor of Punta Toro virus, a member of the Bunyaviridae. For Rift Valley fever virus, which is another Bunyavirus, the activity of 4m was negligible. DHPMs with a C-4 aryl moiety bearing halogen substitution (4b, 4c and 4d) were found to be cytotoxic in MT4 cells.
has issue date	2017-01-15(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2016.12.010
bibo:pmid	27979594
has license	els-covid
sha1sum (hex)	3f185b32a18bfdacbf3ce040737092b60609ded6
schema:url	https://doi.org/10.1016/j.bmcl.2016.12.010
resource representing a document's title	Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones
has PubMed Central identifier	PMC7127791
has PubMed identifier	27979594
schema:publication	Bioorganic & Medicinal Chemistry Letters
resource representing a document's body	covid:3f185b32a18bfdacbf3ce040737092b60609ded6#body_text
is schema:about of	named entity 'IN VITRO' named entity 'EVALUATION' named entity '2C4' named entity 'ANTIVIRAL' named entity 'SYNTHESIS' named entity 'RVFV' named entity 'HeLa' named entity 'African green monkey kidney cells' named entity 'approved drugs' named entity 'fibroblast cells' named entity 'Americas' named entity 'Bunyaviridae' named entity 'halogen' named entity 'feline' named entity 'PTV' named entity 'virus' named entity 'antiviral' named entity 'broad-spectrum' named entity 'cytotoxicity' named entity 'aldehydes' named entity 'RVFV' named entity 'amphiphilic' named entity 'lung' named entity 'cytotoxicity' named entity 'viruses' named entity 'Punta Toro virus' named entity 'entry inhibitor' named entity 'hepatitis B virus' named entity 'sorafenib' named entity 'human population' named entity 'virus' named entity 'therapeutic agents' named entity 'antiviral agent' named entity 'virus' named entity 'cell cultures' named entity 'cell receptors' named entity 'Europe' named entity 'aldehyde' named entity 'mammalian cell' named entity 'brincidofovir' named entity 'aliphatic' named entity 'moiety' named entity 'antiviral medications' named entity 'urea' named entity 'Ethyl' named entity 'RNA viruses' named entity 'Bunyaviridae' named entity 'moiety' named entity 'antiviral activity' named entity 'suramin' named entity 'cervix' named entity 'Rift Valley fever virus' named entity 'RVFV' named entity 'Madin-Darby canine kidney cells' named entity 'Schmallenberg virus' named entity 'Africa' named entity 'cell culture' named entity 'virus' named entity 'biosafety level' named entity 'biochemical' named entity 'livestock' named entity 'aldehyde' named entity 'CD4' named entity 'emerging infectious disease' named entity 'cell morphology' named entity 'virus' named entity 'viral capsid' named entity 'moiety' named entity 'tricyclic compound' named entity 'aldehydes' named entity 'HEL' named entity 'antiviral' named entity 'oxygen' named entity 'amphiphilic'

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